Application of macroautoradiography and instantimage in radiopharmaceutical research

Jeng Jong Hwang, Tzu Chen Yen*, Bor Tsung Hsieh, Gann Ting

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

The evaluation of the pharmacokinetics of pure, beta radiopharmaceuticals is not possible with scintigraphy. Both whole-body autoradiography (WBAR) and Packard Instantimager, a device for rapid imaging, were used to study the whole body distribution of γ- and β-emitting radionuclides (99mTc-MDP, 99mTc-sulfur colloid, or 188Re-HEDP), and results obtained from both methods were compared. The biodistribution of 99mTc-MDP and 188Re-HEDP were seen mainly in bones including skull, spine, and vertebrae of spine and cardiac and skeletal muscles. The 99mTc- sulfur colloid localized in liver, bone marrow, and spleen. The resolution of WBAR is superior than that of Packard Instantimager. However, the advantage of Packard Instantimager is that rapid imaging within few minutes is possible with it, while WBAR imaging requires several hours to days.

原文英語
頁(從 - 到)581-587
頁數7
期刊Journal of Radioanalytical and Nuclear Chemistry
241
發行號3
DOIs
出版狀態已出版 - 1999
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