Armillaria mellea Mycelia Alleviate PM2.5-Induced Pulmonary Inflammation in Murine Models

Yi Ping Huang, Yu Tsen Huang, Hui Yu Wu, Li Fang Chou, You Shan Tsai, Yih Min Jiang, Wan Ping Chen, Ting Wei Lin, Chin Chu Chen*, Chih Ho Lai*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

摘要

Particulate matter (PM) with an aerodynamic diameter of ≤2.5 μm (PM2.5) significantly contributes to various disease-related respiratory inflammations. Armillaria mellea, recognized for its medicinal properties, could alleviate these respiratory ailments. However, its efficacy against PM2.5-induced inflammation remains elusive. In this study, we investigated whether A. mellea mycelia could mitigate PM2.5-induced respiratory inflammation and assessed the underlying mechanisms. Our results showed that A. mellea mycelia significantly reduced PM2.5-induced nitric oxide (NO) production and nuclear factor (NF)-κB activation in macrophages. Furthermore, A. mellea mycelia suppressed the expression of inflammatory mediators, indicating their potent antioxidant and anti-inflammatory properties. In murine models, A. mellea mycelia mitigated PM2.5-induced lung inflammation and cytokine secretion, restoring lung inflammatory status. Our results highlight the potential of A. mellea mycelia to treat PM2.5-induced respiratory inflammation. The antioxidant and anti-inflammatory effects of A. mellea mycelia demonstrated in vitro and in vivo hold promising potential for developing respiratory health improvement interventions upon PM2.5 exposure.

原文英語
文章編號1381
期刊Antioxidants
13
發行號11
DOIs
出版狀態已出版 - 12 11 2024

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© 2024 by the authors.

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