Association of XRCC4 codon 247 polymorphism with oral cancer susceptibility in Taiwan

Hsien Chang Tseng, Ming Hsui Tsai, Chang Fang Chiu, Chung Hsing Wang, Nai Wen Chang, Chih Yang Huang, Chia Wen Tsai, Shiu Yun Liang, Cheng Li Wang, Da Tian Bau*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

43 引文 斯高帕斯(Scopus)

摘要

Background: The DNA repair gene XRCC4, an important caretaker of overall genome stability, is thought to play a major role in the development of human carcinogenesis. However, the association of the polymorphic variants of XRCC4 with oral cancer susceptibility has never been reported. Materials and Methods: In this hospital-based case-control study, the association of XRCC4 codon 247 (rs3734091), G-1394T (rs6869366), intron 7 (rs28360317) and intron 7 (rs1805377) polymorphisms with oral cancer risk in a Central Taiwanese population was investigated. In total, 318 patients with oral cancer and 318 age- and gender-matched healthy controls recruited from the China Medical Hospital in Central Taiwan were genotyped. Results: A significantly different distribution was found in the frequency of the XRCC4 codon 247 genotype, but not the XRCC4 G-1394T or intron 7 genotypes, between the oral cancer and control groups. A/C heterozygosity at XRCC4 codon 247 conferred a significant (2.04-fold) increased risk of oral cancer. As for XRCC4 G-1394T and intron 7 polymorphisms, there was no difference in distribution between the oral cancer and control groups. Gene-environment interactions with smoking, but not with betel quid chewing or alcohol consumption, were significant for XRCC4 codon 247 polymorphism. The XRCC4 codon 247 A/C genotype in association with smoking conferred an increased risk of 3.44 (95% confidence interval = 1.24-9.60) for oral cancer. Conclusion: Our results provide the first evidence that the heterozygous A allele of the XRCC4 codon 247 may be associated with the development of oral cancer and may be a novel useful marker for primary prevention and anticancer intervention.

原文英語
頁(從 - 到)1687-1691
頁數5
期刊Anticancer Research
28
發行號3 A
出版狀態已出版 - 05 2008
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