Association study of the SLC25A12 gene and autism in Han Chinese in Taiwan

Wei Hsien Chien, Yu Yu Wu, Susan Shur Fen Gau*, Yu Shu Huang, Wei Tsen Soong, Yen Nan Chiu, Chia Hsiang Chen

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

35 引文 斯高帕斯(Scopus)

摘要

Purpose: Autism is a childhood-onset neurodevelopmental disorder with a strong genetic component in its etiology. Several studies reported that the solute carrier family 25 member A12 (SLC25A12) gene was associated with autism. This study aimed to replicate this finding in a Han Chinese sample from Taiwan using a population-based case-control approach. Methods: We genotyped two single nucleotide polymorphisms (SNPs, rs2056202 and rs2292813) of the SLC25A12 gene that were previously reported to be associated with autism in 465 patients (402 males and 63 females) and 450 control subjects (227 males and 223 females) from Taiwan. Differences in the genotype, allele, and haplotype frequencies between the two groups were compared. Results: We found no differences in the allele, genotype, or haplotype frequencies of these two SNPs between patients and controls. Conclusions: Our data do not support that the SLC25A12 gene is associated with autism in our population. The discrepant results of other studies may come from the clinical heterogeneity of patients recruited for studies, or the genetic heterogeneity of autism in different populations.

原文英語
頁(從 - 到)189-192
頁數4
期刊Progress in Neuro-Psychopharmacology and Biological Psychiatry
34
發行號1
DOIs
出版狀態已出版 - 20 01 2010
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