Associations among global long interspersed nuclear element-1 DNA methylation, metal exposure, and chronic kidney disease

Yu Mei Hsueh, Mei Chieh Chen, Ying Chin Lin, Chih Yin Wu, Horng Sheng Shiue, Sheng Lun Hsu, Hsi Hsien Chen, Ya Li Huang*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

摘要

Long interspersed nuclear element-1 (LINE-1) methylation serves as an indicator of global DNA methylation. This study explored the correlation between LINE-1 methylation and chronic kidney disease (CKD). We also evaluated whether LINE-1 methylation could modify the association between CKD and metal exposure. A total of 213 patients with clinically defined CKD, without hemodialysis and 416 age and sex matched controls were recruited. Levels of LINE-1 methylation, total urinary arsenic, blood lead, blood cadmium, and plasma selenium were assessed. The results reveal a positive association between LINE-1 methylation and CKD, with an odds ratio (OR) of 5.30 (95% confidence interval: 2.81 to 9.99). Total urinary arsenic and blood cadmium concentrations were positively related with LINE-1 methylation. This study was the first to observe that low plasma selenium, high blood cadmium, and high blood lead levels significantly and additively interact with increased LINE-1 methylation to increase the OR of CKD. Additionally, high LINE-1 methylation interacted multiplicatively with low plasma selenium to increase the OR of CKD (p < 0.001). This study highlighted the significant association between LINE-1 hypermethylation and CKD. Furthermore, the results demonstrate that LINE-1 methylation can interact with high blood cadmium or low plasma selenium to affect CKD risk.

原文英語
頁(從 - 到)3127-3135
頁數9
期刊Archives of Toxicology
98
發行號9
DOIs
出版狀態已出版 - 09 2024

文獻附註

© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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