Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis

Huang Pin Wu, Kong Chung, Chun Yao Lin, Bor Yiing Jiang, Duen Yau Chuang, Yu Chih Liu*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

58 引文 斯高帕斯(Scopus)

摘要

Objective and design: T helper 17 (Th17) and regulatory T (Treg) lymphocytes might play important roles in patients with severe sepsis. The association of Th17 or Treg lymphocytes with survival is also unclear. Methods: Eighty-seven patients with severe sepsis were enrolled from our intensive care units between August 2008 and July 2010. Leukocyte antigens and clinical data were determined on day 1 in all patients and on day 7 in first-year patients. Results: The percentages in peripheral blood mononuclear cells (PBMCs) and circulatory counts of CD4+ and CD8+ lymphocytes in survivors were higher than those in non-survivors. Th1/CD4 + ratios and circulatory Th1 lymphocyte counts in survivors were higher than in non-survivors. Absolute counts of Th17 and Treg lymphocytes in survivors were higher than in non-survivors. The percentages of CD4+ and CD8+ in survivors' PBMCs were increased after 6 days. Th17/CD4+ ratios and circulatory Th17 lymphocyte counts in survivors were increased after 6 days. Conclusions: Higher Th1 differentiation and total CD4+ T lymphocyte counts were associated with higher survival. The association of circulatory Th17 and Treg lymphocytes with mortality in severe sepsis may be due to the change in total CD4 + T lymphocytes. In survivors, Th17 differentiation and counts were restored.

原文英語
頁(從 - 到)751-763
頁數13
期刊Inflammation Research
62
發行號8
DOIs
出版狀態已出版 - 08 2013

指紋

深入研究「Associations of T helper 1, 2, 17 and regulatory T lymphocytes with mortality in severe sepsis」主題。共同形成了獨特的指紋。

引用此