@inproceedings{67811ef59e954b86af0415e5a346df69,
title = "Bio-molecular and cellular detection using SPR sensor and all-transparent microfluidic platform",
abstract = "This paper reports an automated polymer based microfluidic analysis system integrated with a surface plasmon resonance (SPR) biosensor for detecting the specific binding of biomolecules and qualitatively monitoring of cell adhesion on the sensor surface. Micropumps, microchannels, and a SPR biosensor were integrated into a single polymer (PMMA) based microfluidic system. Because SPR based biodetection requires optically transparent substrates, PMMA is a potential replacement for glass and silicon-glass microfluidic systems, if bio-compatibility and low-cost are desired. The integrated system has been studied for its potential applications in bio-molecules detection and drug-discovery. Two experiments, 1) monitoring the reaction between BSA-BSA antibody, and 2) monitoring the activities of living cells in the presence or absence of trypsin in RPMI-1640 medium, were conducted to show its biomedical applications. The experimental setup and results of these tests are presented in this paper.",
keywords = "Biomolecular Detection, Cellular Detection, Microfluidic System, SPR Sensor",
author = "Lei, \{Kin Fong\} and Law, \{Wing Cheung\} and Suen, \{Yick Keung\} and Li, \{Wen J.\} and Ho, \{Ho Pui\} and Chinlon Lin and Kong, \{Siu Kai\}",
year = "2005",
doi = "10.1109/NANO.2005.1500764",
language = "英语",
isbn = "0780391993",
series = "2005 5th IEEE Conference on Nanotechnology",
publisher = "IEEE Computer Society",
pages = "490--493",
booktitle = "2005 5th IEEE Conference on Nanotechnology",
address = "美国",
note = "2005 5th IEEE Conference on Nanotechnology ; Conference date: 11-07-2005 Through 15-07-2005",
}