TY - JOUR
T1 - Bioactive chemical constituents from the brown alga homoeostrichus formosana
AU - Fang, Hui Yu
AU - Chokkalingam, Uvarani
AU - Chiou, Shu Fen
AU - Hwang, Tsong Long
AU - Chen, Shu Li
AU - Wang, Wei Lung
AU - Sheu, Jyh Horng
N1 - Publisher Copyright:
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2015/12/30
Y1 - 2015/12/30
N2 - A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1–6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils.
AB - A new chromene derivative, 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-hydroxy-2,6-dimethyl-2H-chromene (1) together with four known natural products, methylfarnesylquinone (2), isololiolide (3), pheophytin a (4), and β-carotene (5) were isolated from the brown alga Homoeostrichus formosana. The structure of 1 was determined by extensive 1D and 2D spectroscopic analyses. Acetylation of 1 yielded the monoacetylated derivative 2-(4',8'-dimethylnona-3'E,7'-dienyl)-8-acetyl-2,6-dimethyl-2H-chromene (6). Compounds 1–6 exhibited various levels of cytotoxic, antibacterial, and anti-inflammatory activities. Compound 2 was found to display potent in vitro anti-inflammatory activity by inhibiting the generation of superoxide anion (IC50 0.22 ± 0.03 μg/mL) and elastase release (IC50 0.48 ± 0.11 μg/mL) in FMLP/CB-induced human neutrophils.
KW - Anti-inflammatory
KW - Antibacterial
KW - Chromenes
KW - Cytotoxicity
KW - Homoeostrichus formosana
UR - http://www.scopus.com/inward/record.url?scp=84920262562&partnerID=8YFLogxK
U2 - 10.3390/ijms16010736
DO - 10.3390/ijms16010736
M3 - 文章
C2 - 25561228
AN - SCOPUS:84920262562
SN - 1661-6596
VL - 16
SP - 736
EP - 746
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 1
ER -