Biologic properties of three newly established human esophageal carcinoma cell lines

Cheng po Hu; Hsian guey Hsieh; Kwang yu Chien; Pei yen Wang; Ching i. Wang; Chih yi Chen; Szecheng J. Lo; Kuang dong Wuu; Chungming Chang

doi:10.1093/jnci/72.3.577

Biologic properties of three newly established human esophageal carcinoma cell lines

Cheng po Hu^*
, Hsian guey Hsieh
, Kwang yu Chien
, Pei yen Wang
, Ching i. Wang
, Chih yi Chen
, Szecheng J. Lo
, Kuang dong Wuu
, Chungming Chang

^*此作品的通信作者

Veterans General Hospital-Taipei
National Yang Ming Chiao Tung University
Kaohsiung General Veterans Hospital

研究成果: 期刊稿件 › 文章 › 同行評審

72 引文斯高帕斯（Scopus）

摘要

Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.

原文	英語
頁（從 - 到）	577-583
頁數	7
期刊	Journal of the National Cancer Institute
卷	72
發行號	3
DOIs	https://doi.org/10.1093/jnci/72.3.577
出版狀態	已出版 - 03 1984
對外發佈	是

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10.1093/jnci/72.3.577

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title = "Biologic properties of three newly established human esophageal carcinoma cell lines",

abstract = "Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.",

author = "Hu, \{Cheng po\} and Hsieh, \{Hsian guey\} and Chien, \{Kwang yu\} and Wang, \{Pei yen\} and Wang, \{Ching i.\} and Chen, \{Chih yi\} and Lo, \{Szecheng J.\} and Wuu, \{Kuang dong\} and Chungming Chang",

year = "1984",

month = mar,

doi = "10.1093/jnci/72.3.577",

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TY - JOUR

T1 - Biologic properties of three newly established human esophageal carcinoma cell lines

AU - Hu, Cheng po

AU - Hsieh, Hsian guey

AU - Chien, Kwang yu

AU - Wang, Pei yen

AU - Wang, Ching i.

AU - Chen, Chih yi

AU - Lo, Szecheng J.

AU - Wuu, Kuang dong

AU - Chang, Chungming

PY - 1984/3

Y1 - 1984/3

N2 - Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.

AB - Three epithelial cell lines, CE-48T/VGH, CE-69T/-VGH, and CE-81T/VGH, were established from human squamous cell carcinoma of the esophagus. The cells were polygonal with a high nucleus-to-cytoplasm ratio. Many cells were multinucleate. Electron microscopy revealed the presence of tonofilaments and desmosomes. Chromosome analysis showed that these 3 cell lines were heteroploids of human origin. When transplanted into BALB/c (nu/nu) mice, CE-69T/VGH and CE-81T/VGH produced tumors, the histology of which proved to be carcinomas. All 3 cell lines secreted carcinoembryonic antigen. However, the secretion patterns were different. These 3 cell lines may provide useful models for the study of human esophageal cancer.

UR - https://www.scopus.com/pages/publications/0021344920

U2 - 10.1093/jnci/72.3.577

DO - 10.1093/jnci/72.3.577

M3 - 文章

C2 - 6583441

AN - SCOPUS:0021344920

SN - 0027-8874

VL - 72

SP - 577

EP - 583

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 3

ER -

Biologic properties of three newly established human esophageal carcinoma cell lines

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