Bletilla striata Polysaccharide-Containing Carboxymethyl Cellulose Bilayer Structure Membrane for Prevention of Postoperative Adhesion and Achilles Tendon Repair

Zhi Yu Chen, Shih Heng Chen, Shih Hsien Chen, Pang Yun Chou, Che Yung Kuan, I. Hsuan Yang, Chia Tien Chang, Yi Chun Su, Feng Huei Lin*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

摘要

Postoperative tissue adhesion and poor tendon healing are major clinical problems associated with tendon surgery. To avoid postoperative adhesion and promote tendon healing, we developed and synthesized a membrane to wrap the surgical site after tendon suturing. The bilayer-structured porous membrane comprised an outer layer [1,4-butanediol diglycidyl ether cross-linked with carboxymethyl cellulose (CX)] and an inner layer [1,4-butanediol diglycidyl ether cross-linked with Bletilla striata polysaccharides and carboxymethyl cellulose (CXB)]. The morphology, chemical functional groups, and membrane structure were determined. In vitro experiments revealed that the CX/CXB membrane demonstrated good biosafety and biodegradability, promoted tenocyte proliferation and migration, and exhibited low cell attachment and anti-inflammatory effects. Furthermore, in in vivo animal study, the CX/CXB membrane effectively reduced postoperative tendon-peripheral tissue adhesion and improved tendon repair, downregulating inflammatory cytokines in the tendon tissue at the surgical site, which ultimately increased tendon strength by 54% after 4 weeks.

原文英語
頁(從 - 到)5786-5797
頁數12
期刊Biomacromolecules
25
發行號9
DOIs
出版狀態已出版 - 09 09 2024

文獻附註

Publisher Copyright:
© 2024 The Authors. Published by American Chemical Society.

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