TY - JOUR
T1 - Calcifying odontogenic cyst
T2 - Clinicopathological features and immunohistochemical profile of 10 cases
AU - Rodrigues Fregnani, Eduardo
AU - Ramôa Pires, Fábio
AU - Quezada, Rivera Daniel
AU - Shih, Ie Ming
AU - Vargas, Pablo Agustin
AU - De Almeida, Oslei Paes
PY - 2003/3
Y1 - 2003/3
N2 - Background: Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion with few studies describing its immunohistochemical profile and proliferative activity reported in the literature. Methods: Clinical and histological features and immunohistochemical expression of cytokeratins, Mel-CAM (CD146), bcl-2, PCNA and ki-67, in 10 cases of COC were studied. Results: All 10 cases affected the maxilla, eight intraosseous and two peripheral. Five central cases were cystic and three were cystic associated with odontoma, and the two extraosseous showed solid histological pattern; immunohistochemistry was positive for cytokeratins 8, 14, 19, AE1/AE3 and 34βE12 and bcl-2 in all cases, and Mel-CAM in six cases. Proliferative activity was greater in the epithelium of central cystic COC in relation to COC associated with odontoma and peripheral lesions. Conclusion: Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. There were no recurrences after surgery, irrespective of their proliferative activity.
AB - Background: Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion with few studies describing its immunohistochemical profile and proliferative activity reported in the literature. Methods: Clinical and histological features and immunohistochemical expression of cytokeratins, Mel-CAM (CD146), bcl-2, PCNA and ki-67, in 10 cases of COC were studied. Results: All 10 cases affected the maxilla, eight intraosseous and two peripheral. Five central cases were cystic and three were cystic associated with odontoma, and the two extraosseous showed solid histological pattern; immunohistochemistry was positive for cytokeratins 8, 14, 19, AE1/AE3 and 34βE12 and bcl-2 in all cases, and Mel-CAM in six cases. Proliferative activity was greater in the epithelium of central cystic COC in relation to COC associated with odontoma and peripheral lesions. Conclusion: Calcifying odontogenic cysts showed odontogenic cytokeratin profile and bcl-2 and Mel-CAM expression indicate that these proteins may be involved in the development of COC. There were no recurrences after surgery, irrespective of their proliferative activity.
KW - Calcifying odontogenic cyst
KW - CD146
KW - Cytokeratins
KW - Ghost cells
KW - Immunohistochemistry
KW - Mel-CAM
UR - https://www.scopus.com/pages/publications/0037947750
U2 - 10.1034/j.1600-0714.2003.00070.x
DO - 10.1034/j.1600-0714.2003.00070.x
M3 - 文章
C2 - 12581386
AN - SCOPUS:0037947750
SN - 0904-2512
VL - 32
SP - 163
EP - 170
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
IS - 3
ER -