Can microscopic biliary reconstruction reduce biliary complication rate in ABO-incompatible adult living donor liver transplantation?

Yu Cheng Lin, Tsan Shiun Lin, Chih Che Lin, Yueh Wei Liu, Shih Ho Wang, Yi Ju Wu, Wei Feng Li, Yu Hung Lin, Ting Lung Lin, Yi Chia Chan, Cheng Hsi Yeh, Chih Chi Wang, Chao Long Chen, Chee Chien Yong*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background: With the introduction of rituximab, ABO-incompatible (ABOi) living donor liver transplantation (LDLT) has been considered a feasible and safe procedure to overcome the shortage of organ donors. However, higher biliary complication rates remain an unresolved problem in the ABOi group. In our center, biliary anastomosis has been done with microscopic biliary reconstruction (MBR), which effectively reduced the biliary complication rate. The aim of the current study was to investigate whether the microscopic approach reduced anastomotic biliary complications in ABOi LDLT. Material/Methods: From March 2006 to December 2018, 30 adult ABOi and 60 ABO-compatible (ABOc) LDLT patients were select-ed from over 1300 recipients through 1: 2 propensity score-matched cohorts. All patients received MBR dur-ing the transplantation. Biliary complications included bile leakage and biliary stricture. Patients with diffuse intrahepatic biliary stricture were excluded from analysis. Results: Patient characteristics were similar in the 2 groups. There was no in-hospital mortality in the ABOi LDLT. The long-term survival rates of the ABOi patients were comparable to those of the patients that underwent ABOc LDLT (87.1% vs 87.4%, P=0.964). Those in the ABOi group with anastomotic biliary complications were about 40%, which was higher than in the ABOc patients (40% vs 15%, P=0.01). Conclusions: Microscopic biliary reconstruction does not help to reduce the high biliary complication rate in ABOi LDLT. Further investigation and identification regarding other risk factors and precautionary measures involving im-munologic and adaptation mechanisms are needed.

原文英語
文章編號e931963
期刊Annals of Transplantation
26
DOIs
出版狀態已出版 - 2021

文獻附註

Publisher Copyright:
© Ann Transplant, 2021.

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