Carbapenem-resistant Enterobacteriaceae infection in children less than one year old in an Asian medical center

Cha Shien Yen, Hsuan Ling Hsiao, Chien Chung Lee, Tzu Cheng Tsai, Hui Yu Chen, Chyi Liang Chen*, Cheng Hsun Chiu*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

BACKGROUND: The emergence of carbapenem-resistant Enterobacteriaceae (CRE) is a threat to public health worldwide. This study aimed to determine the risk factors and outcomes for CRE colonization and infection in infants.

METHODS: Children aged <1 year hospitalized with CRE pathogens isolated from January 2016 to June 2019 were retrospectively analyzed. Demographic and clinical data were examined.

RESULTS: A total of 48 infections were identified in 70 infants aged <1 year, and 66.7% (32/48) of these infants were born preterm. The infection rate in infants aged <1 month was higher than that of others (P = 0.005). The most commonly isolated CRE was Klebsiella pneumoniae (60.4%, 29/48), followed by Enterobacter cloacae complex (18.8%, 9/48). Sputum (37.5%, 18/48), blood (27.1%, 13/48), and urine (25.0%, 12/48) were the most common clinical samples. Urinary tract infection was common in infants aged 6-12 months. CRE infection was associated with mechanical ventilation (P = 0.037), central venous catheter (CVC) insertion (P = 0.034), and congenital heart disease (P = 0.027). The hospital stay of patients with CRE infection was longer (median, 75 days; SD, 66.4 days), and their all-cause mortality (6.4%) was higher than those with colonization.

CONCLUSIONS: CRE infection was common in infants aged <1 month, and patients usually had longer hospitalization. Carbapenemase production was not common. Mechanical ventilation, CVC insertion, and congenital heart disease were associated with a higher risk of CRE acquisition in infants aged <1 year.

原文英語
頁(從 - 到)168-175
頁數8
期刊Pediatrics and Neonatology
64
發行號2
DOIs
出版狀態已出版 - 03 2023

文獻附註

Copyright © 2022 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved.

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