Cerebrospinal fluid electrolytes and acid-base in diabetic patients

Chia Chih Liao, Te Hsin Hou, Huang Ping Yu, Allen Li, Fu Chao Liu*


研究成果: 期刊稿件文章同行評審

2 引文 斯高帕斯(Scopus)


Background: Diabetes mellitus (DM) has detrimental effects on the function of microvascular beds, resulting in blood-brain barrier (BBB) dysfunction. The objective of the study was to investigate whether DM affects the brain physiology through composition of cerebrospinal fluid (CSF) and compare gas tension and electrolyte levels in CSF between the diabetic and nondiabetic populations. Methods: Patients aged between 20 and 70 years scheduled for elective orthopedic or urologic surgery requiring spinal anesthesia were enrolled. They were assigned to either of the two groups (control or type 2 DM). Gas tension and electrolytes in the CSF and whole blood samples were measured in both groups. Results: All 49 enrolled patients (24 in the control and 25 in the DM group) completed the study. The concentrations of Na+ and Mg2+ in the blood were significantly lower in the DM group than those in the control. The levels of pCO2 and HCO3- in the CSF were lower in the DM group than in the control group. In addition, there was a marked increase in the glucose level in both the blood and CSF in the DM group. Conclusion: The results show that there were some homeostatic changes in blood and CSF in patients with DM.

頁(從 - 到)448-455
期刊Translational Neuroscience
出版狀態已出版 - 01 01 2021


Publisher Copyright:
© 2021 Chia-Chih Liao et al., published by De Gruyter.


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