Changes in corneal basal epithelial phenotypes in an altered basement membrane

I. Jong Wang, Ray Jui Fang Tsai, Lung Kun Yeh, Ryan Yao Nien Tsai, Fung Rong Hu, Winston W.Y. Kao

研究成果: 期刊稿件文章同行評審

7 引文 斯高帕斯(Scopus)

摘要

Background: To examine the corneal epithelial phenotype in an altered basement membrane. Methodology/Principal Findings: Corneas from 9 patients with symptoms of continuous unstable corneal curvature (CUCC) were harvested by penetrating keratoplasty and subjected to histology examination and immunohistochemical staining with transactivating and N-terminally truncated pP63 transcript (DNp63), cytokeratin 3 (Krt3), ATP-binding cassette subfamily G member 2 (ABCG2), connexin 43 (CX43), p38 mitogen-activated protein kinases (p38MAPK), activating protein 2 (TFAP2), and extracellular signal-regulated kinase (Erk1/2) monoclonal antibodies. Positive immunostaining with ABCG2, p38MAPK, and TFAP2 monoclonal antibodies was observed in the basal epithelial cells of CUCC patients, and CX43 and DNp63 were detected in the full-thickness epithelial cells of CUCC patients. Conclusions/Significance: Our results indicate that alteration of the corneal basement membrane induces a dedifferentiation- like phenotype in corneal basal epithelial cells.

原文英語
文章編號e14537
期刊PLoS ONE
6
發行號1
DOIs
出版狀態已出版 - 2011
對外發佈

指紋

深入研究「Changes in corneal basal epithelial phenotypes in an altered basement membrane」主題。共同形成了獨特的指紋。

引用此