Characteristics of pre-S2 region of hepatitis B virus

Szecheng J. Lo*, Ming Lii Chen, Mei Ling Chien, Yan Hwa Wu Lee

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.

原文英語
頁(從 - 到)382-388
頁數7
期刊Biochemical and Biophysical Research Communications
135
發行號2
DOIs
出版狀態已出版 - 13 03 1986
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