TY - JOUR
T1 - Characterizing Two Hybrid Exercise-Cognitive Training Interventions With Neurophysiological and Behavioral Indexes in Post-Stroke Patients With Cognitive Dysfunction
T2 - A Randomized Controlled Trial
AU - Liu, Chia Lun
AU - Huang, Shou Hsien
AU - Wang, Wei Chun
AU - Chen, Chih Kuang
AU - Su, Ken Hsien
AU - Wu, Ching Yi
N1 - Publisher Copyright:
© 2001-2011 IEEE.
PY - 2024
Y1 - 2024
N2 - Combined exercise and cognitive training have been evidenced to be effective in cognitive and physical functions in post-stroke survivors. Recent interest has gradually shifted to technology-aided cognitive rehabilitation. However, clear neural makers or comprehensive behavioral indexes used for evaluating rehabilitation remain unexplored. The study aimed to examine the effects of two types of combined exercise-cognitive training on stroke patients with cognitive dysfunction, focusing on neural and behavioral markers. 39 patients were randomly assigned to sequential exercise-cognitive training, simultaneous exercise-cognitive training or active control groups and underwent 60 minutes/day training, 3 days/week, for 12 weeks. 29 patients ultimately completed the training. The markers/indexes included cognitive function, physical function, instrumental activities of daily living, and caregiver strain. Cognitive function included working memory task performance, neurophysiological markers, and cognitive indexes. The results indicated no d-prime difference between groups after the training. The simultaneous training demonstrated significant improvements in the neurophysiological marker of P300 and theta coherence compared to the other groups. Moreover, the simultaneous training also led to significant enhancements in physical function, as measured by the Rivermead Mobility Index, comparing to the other groups. Further analysis contrasting the two exercise-cognitive trainings revealed that improvements in cognition and multifaceted domains (i.e., instrumental activities of daily living and caregiver strain) were manifested in the simultaneous training. Together with the neural markers identified in the current interventions, the differential impacts of the two interventions indicates the potential of technology-driven and personalized rehabilitation in post-stroke patients.
AB - Combined exercise and cognitive training have been evidenced to be effective in cognitive and physical functions in post-stroke survivors. Recent interest has gradually shifted to technology-aided cognitive rehabilitation. However, clear neural makers or comprehensive behavioral indexes used for evaluating rehabilitation remain unexplored. The study aimed to examine the effects of two types of combined exercise-cognitive training on stroke patients with cognitive dysfunction, focusing on neural and behavioral markers. 39 patients were randomly assigned to sequential exercise-cognitive training, simultaneous exercise-cognitive training or active control groups and underwent 60 minutes/day training, 3 days/week, for 12 weeks. 29 patients ultimately completed the training. The markers/indexes included cognitive function, physical function, instrumental activities of daily living, and caregiver strain. Cognitive function included working memory task performance, neurophysiological markers, and cognitive indexes. The results indicated no d-prime difference between groups after the training. The simultaneous training demonstrated significant improvements in the neurophysiological marker of P300 and theta coherence compared to the other groups. Moreover, the simultaneous training also led to significant enhancements in physical function, as measured by the Rivermead Mobility Index, comparing to the other groups. Further analysis contrasting the two exercise-cognitive trainings revealed that improvements in cognition and multifaceted domains (i.e., instrumental activities of daily living and caregiver strain) were manifested in the simultaneous training. Together with the neural markers identified in the current interventions, the differential impacts of the two interventions indicates the potential of technology-driven and personalized rehabilitation in post-stroke patients.
KW - Cognitive dysfunction
KW - EEG
KW - Neurorehabilitation
KW - Stroke
KW - Cognitive Dysfunction/etiology
KW - Stroke/complications
KW - Stroke Rehabilitation/methods
KW - Humans
KW - Middle Aged
KW - Male
KW - Treatment Outcome
KW - Electroencephalography
KW - Activities of Daily Living
KW - Female
KW - Aged
KW - Event-Related Potentials, P300
KW - Exercise Therapy/methods
KW - Cognitive Behavioral Therapy/methods
KW - Memory, Short-Term
KW - Cognitive Training
UR - http://www.scopus.com/inward/record.url?scp=85207340144&partnerID=8YFLogxK
U2 - 10.1109/TNSRE.2024.3482328
DO - 10.1109/TNSRE.2024.3482328
M3 - 文章
C2 - 39418153
AN - SCOPUS:85207340144
SN - 1534-4320
VL - 32
SP - 3913
EP - 3922
JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering
JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering
ER -