Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam; Po Hsun Chen; Hsin Yi Hung; Tsong Long Hwang; Chih Chao Chiang; Tran Dinh Thang; Ping Chung Kuo; Tian Shung Wu

doi:10.3390/molecules23102541

Chemical constituents from the stems of tinospora sinensis and their bioactivity

Sio Hong Lam, Po Hsun Chen, Hsin Yi Hung, Tsong Long Hwang, Chih Chao Chiang, Tran Dinh Thang, Ping Chung Kuo^*, Tian Shung Wu

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

研究成果: 期刊稿件 › 文章 › 同行評審

27 引文斯高帕斯（Scopus）

摘要

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

原文	英語
文章編號	2541
期刊	Molecules
卷	23
發行號	10
DOIs	https://doi.org/10.3390/molecules23102541
出版狀態	已出版 - 05 10 2018

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abstract = "Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.",

keywords = "Elastase release, Lignan, Menispermaceae, Pyrrole alkaloid, Superoxide anion generation",

author = "Lam, {Sio Hong} and Chen, {Po Hsun} and Hung, {Hsin Yi} and Hwang, {Tsong Long} and Chiang, {Chih Chao} and Thang, {Tran Dinh} and Kuo, {Ping Chung} and Wu, {Tian Shung}",

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AU - Lam, Sio Hong

AU - Chen, Po Hsun

AU - Hung, Hsin Yi

AU - Hwang, Tsong Long

AU - Chiang, Chih Chao

AU - Thang, Tran Dinh

AU - Kuo, Ping Chung

AU - Wu, Tian Shung

PY - 2018/10/5

Y1 - 2018/10/5

N2 - Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

AB - Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)- induced superoxide anion generation and elastase release.

KW - Elastase release

KW - Lignan

KW - Menispermaceae

KW - Pyrrole alkaloid

KW - Superoxide anion generation

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DO - 10.3390/molecules23102541

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AN - SCOPUS:85054530915

SN - 1420-3049

VL - 23

JO - Molecules

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Chemical constituents from the stems of tinospora sinensis and their bioactivity

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