Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Che Wei Lin; Tsong Long Hwang; Fu An Chen; Chia Hsin Huang; Hsin Yi Hung; Tian Shung Wu

doi:10.1021/acs.jnatprod.6b00118

Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

Che Wei Lin, Tsong Long Hwang, Fu An Chen, Chia Hsin Huang, Hsin Yi Hung^*, Tian Shung Wu

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

研究成果: 期刊稿件 › 文章 › 同行評審

48 引文斯高帕斯（Scopus）

摘要

Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC₅₀ values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

原文	英語
頁（從 - 到）	1911-1921
頁數	11
期刊	Journal of Natural Products
卷	79
發行號	8
DOIs	https://doi.org/10.1021/acs.jnatprod.6b00118
出版狀態	已出版 - 26 08 2016

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Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.

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10.1021/acs.jnatprod.6b00118

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title = "Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity",

abstract = "Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.",

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AU - Lin, Che Wei

AU - Hwang, Tsong Long

AU - Chen, Fu An

AU - Huang, Chia Hsin

AU - Hung, Hsin Yi

AU - Wu, Tian Shung

PY - 2016/8/26

Y1 - 2016/8/26

N2 - Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

AB - Nine new phenanthrenes (1-9) and a new benzyl glycoside (10) together with 45 known compounds were isolated from the rhizomes of Bletilla formosana. The structures of 1-10 were elucidated primarily on the basis of their 1D and 2D NMR spectroscopic data. Most of the isolated compounds were evaluated for their anti-inflammatory activities. The results showed that IC50 values for the inhibition of superoxide anion generation and elastase release ranged from 0.2 to 6.5 μM and 0.3 to 5.7 μM, respectively. Structure-activity relationships of the isolated compounds were also investigated. The inhibitory potencies were determined as phenanthrenes > bibenzyls > biphenanthrenes.

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SN - 0163-3864

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Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity

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