TY - JOUR
T1 - Chitosan
T2 - Applications in Drug Delivery System
AU - Kumar, Suresh
AU - Dhiman, Ruby
AU - Prudencio, Carlos R.
AU - da Costa, Antonio Charlys
AU - Vibhuti, Arpana
AU - Leal, Elcio
AU - Chang, Chung Ming
AU - Raj, Vethakkani Samuel
AU - Pandey, Ramendra Pati
N1 - Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
PY - 2023/4
Y1 - 2023/4
N2 - Chitin and chitosan have unique structures with significant functional groups carrying useful chemical capabilities. Chitin and chitosan are acknowledged as novel biomaterials with ad-vantageous biocompatibility and biodegradability. Chitosan is a polysaccharide that is made from chitin. There have been several attempts to employ this biopolymer in the biomedical area. This ma-terial's application in the production of artificial skin, drug targeting, and other areas is explored. The most prevalent strategies for recovering chitin from sea organisms are described and various pharmacological and biological uses are discussed. This review article targets drug delivery with the help of chitosan derived nanomaterial. The drug delivery system applications through nonmaterial have encountered a considerable role in the pharmaceutical, medical, biological, and other sectors in recent years. Nanomaterials have advanced applications as novel drug delivery systems in many fields, especially in industry, biology, and medicine. In the biomedical and pharmaceutical arena, the natural polymer-based nanoparticulate method has now been widely studied as particulate vehicles. By mixing alginate with other biopolymers, by immobilizing specific molecules such as sugar molecules and peptides by chemical or physical cross-linking, different properties and structures such as biodegradability, gelling properties, mechanical strength, and cell affinity can be obtained. Owing to their inherent ability to deliver both hydrophilic and hydrophobic drug molecules, increase stability, decrease toxicity, and enhance commonly formulated medications, these particles are now widely used in imaging and molecular diagnostics, cosmetics, household chemicals, sunscreens, radiation safety, and novel drug delivery.
AB - Chitin and chitosan have unique structures with significant functional groups carrying useful chemical capabilities. Chitin and chitosan are acknowledged as novel biomaterials with ad-vantageous biocompatibility and biodegradability. Chitosan is a polysaccharide that is made from chitin. There have been several attempts to employ this biopolymer in the biomedical area. This ma-terial's application in the production of artificial skin, drug targeting, and other areas is explored. The most prevalent strategies for recovering chitin from sea organisms are described and various pharmacological and biological uses are discussed. This review article targets drug delivery with the help of chitosan derived nanomaterial. The drug delivery system applications through nonmaterial have encountered a considerable role in the pharmaceutical, medical, biological, and other sectors in recent years. Nanomaterials have advanced applications as novel drug delivery systems in many fields, especially in industry, biology, and medicine. In the biomedical and pharmaceutical arena, the natural polymer-based nanoparticulate method has now been widely studied as particulate vehicles. By mixing alginate with other biopolymers, by immobilizing specific molecules such as sugar molecules and peptides by chemical or physical cross-linking, different properties and structures such as biodegradability, gelling properties, mechanical strength, and cell affinity can be obtained. Owing to their inherent ability to deliver both hydrophilic and hydrophobic drug molecules, increase stability, decrease toxicity, and enhance commonly formulated medications, these particles are now widely used in imaging and molecular diagnostics, cosmetics, household chemicals, sunscreens, radiation safety, and novel drug delivery.
KW - Biopolymers
KW - biological properties
KW - nanomaterials
KW - nanotoxicity
KW - pharmaceutical nano-technology
KW - physicochemical properties
KW - toxicological effect
KW - Chitin/chemistry
KW - Biocompatible Materials/chemistry
KW - Pharmaceutical Preparations
KW - Chitosan/chemistry
KW - Drug Delivery Systems
UR - http://www.scopus.com/inward/record.url?scp=85143620210&partnerID=8YFLogxK
U2 - 10.2174/1389557522666220609102010
DO - 10.2174/1389557522666220609102010
M3 - 文献综述
C2 - 35692143
AN - SCOPUS:85143620210
SN - 1389-5575
VL - 23
SP - 187
EP - 191
JO - Mini-Reviews in Medicinal Chemistry
JF - Mini-Reviews in Medicinal Chemistry
IS - 2
ER -