TY - JOUR
T1 - Chronic inflammation and hepatocellular carcinoma.
AU - Alison, Malcolm R.
AU - Nicholson, Linda J.
AU - Lin, Wey Ran
PY - 2011
Y1 - 2011
N2 - Hepatocellular carcinoma (HCC) invariably develops within a setting of chronic inflammation caused by either hepatotropic viruses, toxins, metabolic liver disease or autoimmunity. Mechanisms that link these two processes are not completely understood, but transcription factors of the NF-κB family and signal transducer and activator of transcription 3 (STAT3), cytokines such as IL-6 and IL-1α and ligands of the epidermal growth factor receptor (EGFR) family are clearly pivotal players. HCC may have its origins in either hepatocytes or hepatic progenitor cells (HPCs), and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.
AB - Hepatocellular carcinoma (HCC) invariably develops within a setting of chronic inflammation caused by either hepatotropic viruses, toxins, metabolic liver disease or autoimmunity. Mechanisms that link these two processes are not completely understood, but transcription factors of the NF-κB family and signal transducer and activator of transcription 3 (STAT3), cytokines such as IL-6 and IL-1α and ligands of the epidermal growth factor receptor (EGFR) family are clearly pivotal players. HCC may have its origins in either hepatocytes or hepatic progenitor cells (HPCs), and HCCs, like other solid tumours appear to be sustained by a minority population of cancer stem cells.
UR - http://www.scopus.com/inward/record.url?scp=84856394989&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-03503-6_8
DO - 10.1007/978-3-642-03503-6_8
M3 - 文献综述
C2 - 21822824
AN - SCOPUS:84856394989
SN - 0080-0015
VL - 185
SP - 135
EP - 148
JO - Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
JF - Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer
ER -
