TY - JOUR
T1 - Circulating level of endothelial progenitor cells in healthy Taiwanese
AU - Chen, Chih Hung
AU - Cheng, Ben Chung
AU - Leu, Steven
AU - Sun, Cheuk Kwan
AU - Chua, Sarah
AU - Yen, Chia Hung
AU - Kung, Chia Te
AU - Chen, Yen Ta
AU - Chang, Li Teh
AU - Yip, Hon Kan
PY - 2010/6
Y1 - 2010/6
N2 - Background: The relationship between circulating level of endothelial progenitor cells (EPCs) and general physical characteristics in healthy Taiwanese remains unclear. Taiwanese population of all ages participating in a health screening program in our Health Clinic was studied. Methods: Circulating EPC levels in blood samples prospectively collected from 100 study subjects once at 8:00 a.m. from antecubital vein were determined. Levels of circulating EPCs (staining markers: CD31/CD34, CD62E/CD34, and KDR/CD34) were examined by flow cytometry. Results: The mean circulating level of CD31/CD34, CD62E/CD34, and KDR/CD34 were 1.3 ± 1.0%, 1.2 ± 1.2% and 1.2 ± 1.0%, respectively. No correlation was noted among circulating level of EPCs and the levels of serum triglyceride, total cholesterol, high-density or low-density lipoprotein, blood glucose, and creatinine (all p > 0.1). There was also no association between circulating level of EPCs and systolic or diastolic blood pressure, liver function, current smoking status, gender, and body mass index (all p > 0.1). However, there was a significant direct correlation between EPC (CD62E/CD34) level and platelet count (p = 0.044). On the other hand, EPC (KDR/CD34) level was inversely proportional to white blood cell (WBC) count (p = 0.009) and age (p = 0.031). Conclusion: In healthy Taiwanese population, circulating level of EPCs was significantly associated with an increase in platelet count and inversely associated with WBC count and age.
AB - Background: The relationship between circulating level of endothelial progenitor cells (EPCs) and general physical characteristics in healthy Taiwanese remains unclear. Taiwanese population of all ages participating in a health screening program in our Health Clinic was studied. Methods: Circulating EPC levels in blood samples prospectively collected from 100 study subjects once at 8:00 a.m. from antecubital vein were determined. Levels of circulating EPCs (staining markers: CD31/CD34, CD62E/CD34, and KDR/CD34) were examined by flow cytometry. Results: The mean circulating level of CD31/CD34, CD62E/CD34, and KDR/CD34 were 1.3 ± 1.0%, 1.2 ± 1.2% and 1.2 ± 1.0%, respectively. No correlation was noted among circulating level of EPCs and the levels of serum triglyceride, total cholesterol, high-density or low-density lipoprotein, blood glucose, and creatinine (all p > 0.1). There was also no association between circulating level of EPCs and systolic or diastolic blood pressure, liver function, current smoking status, gender, and body mass index (all p > 0.1). However, there was a significant direct correlation between EPC (CD62E/CD34) level and platelet count (p = 0.044). On the other hand, EPC (KDR/CD34) level was inversely proportional to white blood cell (WBC) count (p = 0.009) and age (p = 0.031). Conclusion: In healthy Taiwanese population, circulating level of EPCs was significantly associated with an increase in platelet count and inversely associated with WBC count and age.
KW - Endothelial progenitor cells
KW - Healthy Taiwanese
UR - http://www.scopus.com/inward/record.url?scp=77955892576&partnerID=8YFLogxK
M3 - 文章
AN - SCOPUS:77955892576
SN - 1011-6842
VL - 26
SP - 94
EP - 101
JO - Acta Cardiologica Sinica
JF - Acta Cardiologica Sinica
IS - 2
ER -