Clinical characteristics and functional dependent risk of intracerebral hemorrhage in patients with nephrotic syndrome

Wen Yi Huang, Chun Wei Chang, Kuan Hsing Chen, Chien Hung Chang, Hsiu Chuan Wu, Kuo Hsuan Chang*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

摘要

BACKGROUND: While an increased incidence of intracerebral hemorrhage (ICH) has been reported in patients with nephrotic syndrome (NS), comprehensive understanding of the characteristics of ICH in this population remains elusive. This study explored the clinical features of ICH in a larger cohort of NS patients.

METHODS: To compare the clinical characteristics of ICH in patients with and without NS, we conducted a multi-institutional retrospective cohort study using the data from Chang Gung Research Database of Taiwan from January 1, 2001, to December 31, 2017.

RESULTS: This study enrolled a total of 120 ICH patients with NS, and 271 ICH patients without NS. Patients with NS had a longer average length of stay in the acute medicine ward (17.7 ± 15.9 days vs 14.4 ±13.3 days, P = 0.047) and higher incidence of urinary tract infection (20.0% vs 10.0%, P = 0.006), gastrointestinal bleeding (16.7% vs 4.8%, P < 0.001), and pulmonary edema (4.2% vs 0%, P = 0.003) compared to those without ICH. Furthermore, the risk of 30-day dependent outcome (modified Rankin Scale score≧3) was significantly higher in ICH patients with NS compared to those without NS (Odds ratio 3.43, 95% confidence interval 1.49 to 7.91, P = 0.004). However, the 30-day mortality rate was similar between the NS patients and the control group.

CONCLUSIONS: NS is associated with a significantly increased risk of functional dependence following ICH, highlighting the critical need for tailored intensive treatment and rehabilitation specifically for this patient population.

原文英語
文章編號108038
頁(從 - 到)108038
期刊Journal of Stroke and Cerebrovascular Diseases
33
發行號12
早期上線日期25 09 2024
DOIs
出版狀態已出版 - 12 2024

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