Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

P. H. Tan; L. C. Yang; H. C. Shih; C. R. Lin; K. C. Lan; C. S. Chen

doi:10.1046/j.1365-2044.2002.02624_4.x

Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

P. H. Tan^*, L. C. Yang, H. C. Shih, C. R. Lin, K. C. Lan, C. S. Chen

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

30 引文斯高帕斯（Scopus）

摘要

We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg^-1) and nicardipine (15 or 30 μg.kg^-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg^-1 and nicardipine 30 μg.kg^-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

原文	英語
頁（從 - 到）	1207-1212
頁數	6
期刊	Anaesthesia
卷	57
發行號	12
DOIs	https://doi.org/10.1046/j.1365-2044.2002.02624_4.x
出版狀態	已出版 - 01 12 2002
對外發佈	是

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abstract = "We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg-1) and nicardipine (15 or 30 μg.kg-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg-1 and nicardipine 30 μg.kg-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).",

keywords = "Calcium-channel blockers: nicardipine, Intubation: tracheal, Sympathetic nervous system: α adrenergic antagonists, esmolol",

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T1 - Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

AU - Tan, P. H.

AU - Yang, L. C.

AU - Shih, H. C.

AU - Lin, C. R.

AU - Lan, K. C.

AU - Chen, C. S.

PY - 2002/12/1

Y1 - 2002/12/1

N2 - We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg-1) and nicardipine (15 or 30 μg.kg-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg-1 and nicardipine 30 μg.kg-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

AB - We examined the effect of different combinations of esmolol and nicardipine upon the circulatory response to tracheal intubation. One hundred patients were randomly allocated into five groups of twenty to receive pretreatments of saline or different combinations of esmolol (0.5 or 1.0 mg.kg-1) and nicardipine (15 or 30 μg.kg-1). Significant tachycardia persisted over a 5-min period after intubation in all five groups compared with baseline levels (p < 0.05). Patients receiving esmolol 1.0 mg.kg-1 and nicardipine 30 μg.kg-1 showed no significant change in systolic blood pressure after tracheal intubation compared with baseline and significant lower peak systolic blood pressure than those receiving saline (p = 0.023).

KW - Calcium-channel blockers: nicardipine

KW - Intubation: tracheal

KW - Sympathetic nervous system: α adrenergic antagonists, esmolol

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Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation

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