Comparison of the effects of etomidate, propofol, and thiopental on respiratory resistance after tracheal intubation

Wendell O. Eames, G. Alec Rooke, Rick Sai Chuen Wu, Michael J. Bishop*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

157 引文 斯高帕斯(Scopus)

摘要

Background: Tracheal intubation frequently results in reversible bronchoconstriction. Propofol has been reported to minimize this response in healthy patients and in asthma patients, but may be unsuitable for hemodynamically unstable patients for whom etomidate may be preferable. The current study examined respiratory resistance after tracheal intubation after induction with either thiopental, etomidate, or propofol. A supratherapeutic dose of etomidate was used to test the hypothesis that the bronchoconstrictive response could be minimized by deep intravenous anesthesia. Methods: Seventy-seven studies were conducted in 75 patients. Anesthesia was induced with either 2.5 mg/kg propofol, 0.4 mg/kg etomidate, or 5 mg/kg thiopental. Respiratory resistance was measured at 2 min after induction. Results: Respiratory resistance at 2 min was 8.1 ± 3.4 cmH 2O · l -1 · s (mean ± SD) for patients receiving propofol versus 11.3 ± 5.3 for patients receiving etomidate and 12.3 ± 7.9 for patients receiving thiopental (P ≤ 0.05 for propofol vs. either etomidate or thiopental). Conclusions: Respiratory resistance after tracheal intubation is lower after induction with propofol than after induction with thiopental or after induction with high-dose etomidate.

原文英語
頁(從 - 到)1307-1311
頁數5
期刊Anesthesiology
84
發行號6
DOIs
出版狀態已出版 - 1996

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