TY - JOUR
T1 - Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy
T2 - A Case Report
AU - Jia, Chenhao
AU - Wu, Meiqi
AU - Yen, Tzu Chen
AU - Li, Yanfeng
AU - Cui, Ruixue
N1 - Publisher Copyright:
© Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.
AB - A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.
KW - atypical parkinsonian syndromes
KW - dopamine transporter function
KW - positron emission tomography
KW - progressive supranuclear palsy
KW - tau imaging
UR - http://www.scopus.com/inward/record.url?scp=85125679765&partnerID=8YFLogxK
U2 - 10.1097/RLU.0000000000003974
DO - 10.1097/RLU.0000000000003974
M3 - 文献综述
C2 - 35020665
AN - SCOPUS:85125679765
SN - 0363-9762
VL - 47
SP - 336
EP - 338
JO - Clinical Nuclear Medicine
JF - Clinical Nuclear Medicine
IS - 4
ER -