Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report

Chenhao Jia; Meiqi Wu; Tzu Chen Yen; Yanfeng Li; Ruixue Cui

doi:10.1097/RLU.0000000000003974

Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report

Chenhao Jia
, Meiqi Wu
, Tzu Chen Yen
, Yanfeng Li
, Ruixue Cui^*

^*此作品的通信作者

Chinese Academy of Medical Sciences
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine
Ltd.

研究成果: 期刊稿件 › 文獻綜述 › 同行評審

3 引文斯高帕斯（Scopus）

摘要

A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.

原文	英語
頁（從 - 到）	336-338
頁數	3
期刊	Clinical Nuclear Medicine
卷	47
發行號	4
DOIs	https://doi.org/10.1097/RLU.0000000000003974
出版狀態	已出版 - 01 04 2022
對外發佈	是

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title = "Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report",

abstract = "A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.",

keywords = "atypical parkinsonian syndromes, dopamine transporter function, positron emission tomography, progressive supranuclear palsy, tau imaging",

author = "Chenhao Jia and Meiqi Wu and Yen, \{Tzu Chen\} and Yanfeng Li and Ruixue Cui",

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T1 - Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy

T2 - A Case Report

AU - Jia, Chenhao

AU - Wu, Meiqi

AU - Yen, Tzu Chen

AU - Li, Yanfeng

AU - Cui, Ruixue

PY - 2022/4/1

Y1 - 2022/4/1

N2 - A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.

AB - A 50-year-old woman developed gait disturbances, tendency to fall backwards, bradykinesia, and memory loss over the previous 6 months. Brain 18F-FDG PET/CT was unable to distinguish among APSs (atypical parkinsonian syndromes); PET investigations of dopamine transporter (DAT) function (11C-CFT) and tau pathology (18F-APN-1607) were performed. 11C-CFT PET revealed severe loss of striatal DAT function, whereas significant tau accumulation was observed in the brainstem, basal ganglia, and globus pallidus on 18F-APN-1607 PET. Such finding suggested diagnosis of PSP (progressive supranuclear palsy). This case highlights the value of DAT and tau PET imaging in diagnosis of PSP and differential diagnosis ofAPSs.

KW - atypical parkinsonian syndromes

KW - dopamine transporter function

KW - positron emission tomography

KW - progressive supranuclear palsy

KW - tau imaging

UR - https://www.scopus.com/pages/publications/85125679765

U2 - 10.1097/RLU.0000000000003974

DO - 10.1097/RLU.0000000000003974

M3 - 文献综述

C2 - 35020665

AN - SCOPUS:85125679765

SN - 0363-9762

VL - 47

SP - 336

EP - 338

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

IS - 4

ER -

Complementary Utility of Dopamine Transporter and Tau PET Imaging in the Diagnosis of Progressive Supranuclear Palsy: A Case Report

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