Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

De Yang Shen; Ping Chung Kuo; Shiow Chyn Huang; Tsong Long Hwang; Yu Yi Chan; Po Chuen Shieh; Nguyen Thi Ngan; Tran Dinh Thang; Tian Shung Wu

doi:10.1007/s11418-016-1033-x

Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

De Yang Shen
, Ping Chung Kuo
, Shiow Chyn Huang
, Tsong Long Hwang
, Yu Yi Chan
, Po Chuen Shieh
, Nguyen Thi Ngan
, Tran Dinh Thang
, Tian Shung Wu^*

^*此作品的通信作者

中醫學系(含學士班、天然藥物、傳統中醫藥碩士班)

National Cheng Kung University
Chia Nan University of Pharmacy and Science
Southern Taiwan University of Science and Technology
Tajen University
Vinh University

研究成果: 期刊稿件 › 文章 › 同行評審

34 引文斯高帕斯（Scopus）

摘要

Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC₅₀ values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

原文	英語
頁（從 - 到）	96-104
頁數	9
期刊	Journal of Natural Medicines
卷	71
發行號	1
DOIs	https://doi.org/10.1007/s11418-016-1033-x
出版狀態	已出版 - 01 01 2017

文獻附註

Publisher Copyright:
© 2016, The Japanese Society of Pharmacognosy and Springer Japan.

存取文件

10.1007/s11418-016-1033-x

其它文件與鏈接

Link to publication in Scopus

引用此

@article{79df48ee05994a779585fe864adb5ca0,

title = "Constituents from the leaves of Clausena lansium and their anti-inflammatory activity",

abstract = "Five new acyclic amides, clausenalansamides C-G (1{\textendash}5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1{\textendash}5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.",

keywords = "Anti-inflammatory, Clausenalansamide, Electronic circular dichroism, Single-crystal X-ray diffraction analysis, Superoxide anion generation",

author = "Shen, \{De Yang\} and Kuo, \{Ping Chung\} and Huang, \{Shiow Chyn\} and Hwang, \{Tsong Long\} and Chan, \{Yu Yi\} and Shieh, \{Po Chuen\} and Ngan, \{Nguyen Thi\} and Thang, \{Tran Dinh\} and Wu, \{Tian Shung\}",

note = "Publisher Copyright: {\textcopyright} 2016, The Japanese Society of Pharmacognosy and Springer Japan.",

year = "2017",

month = jan,

day = "1",

doi = "10.1007/s11418-016-1033-x",

language = "英语",

volume = "71",

pages = "96--104",

journal = "Journal of Natural Medicines",

issn = "1340-3443",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

AU - Shen, De Yang

AU - Kuo, Ping Chung

AU - Huang, Shiow Chyn

AU - Hwang, Tsong Long

AU - Chan, Yu Yi

AU - Shieh, Po Chuen

AU - Ngan, Nguyen Thi

AU - Thang, Tran Dinh

AU - Wu, Tian Shung

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

AB - Five new acyclic amides, clausenalansamides C-G (1–5), clausenaline G (6) and (±)-5-(4-methylphenyl)-γ-valerolactone (7) reported from the natural source for the first time, were characterized from the leaves of Clausena lansium. Their structures were established by spectroscopic and spectrometric methods, and the absolute configurations of new compounds 1–5 were determined by electronic circular dichroism and single-crystal X-ray diffraction analyses. Eighteen compounds were evaluated for their anti-inflammatory activity and only imperatorin (11) and wampetin (12) displayed significant inhibition of fMLP/CB-induced superoxide anion generation with IC50 values of 1.7 ± 0.3 and 6.8 ± 1.1 μM, respectively.

KW - Anti-inflammatory

KW - Clausenalansamide

KW - Electronic circular dichroism

KW - Single-crystal X-ray diffraction analysis

KW - Superoxide anion generation

UR - https://www.scopus.com/pages/publications/84982253576

U2 - 10.1007/s11418-016-1033-x

DO - 10.1007/s11418-016-1033-x

M3 - 文章

C2 - 27539584

AN - SCOPUS:84982253576

SN - 1340-3443

VL - 71

SP - 96

EP - 104

JO - Journal of Natural Medicines

JF - Journal of Natural Medicines

IS - 1

ER -

Constituents from the leaves of Clausena lansium and their anti-inflammatory activity

摘要

文獻附註

存取文件

其它文件與鏈接

指紋

引用此