TY - JOUR
T1 - COVID-19 Is a Multi-Organ Aggressor
T2 - Epigenetic and Clinical Marks
AU - Kgatle, Mankgopo Magdeline
AU - Lawal, Ismaheel Opeyemi
AU - Mashabela, Gabriel
AU - Boshomane, Tebatso Moshoeu Gillian
AU - Koatale, Palesa Caroline
AU - Mahasha, Phetole Walter
AU - Ndlovu, Honest
AU - Vorster, Mariza
AU - Rodrigues, Hosana Gomes
AU - Zeevaart, Jan Rijn
AU - Gordon, Siamon
AU - Moura-Alves, Pedro
AU - Sathekge, Mike Machaba
N1 - Publisher Copyright:
© Copyright © 2021 Kgatle, Lawal, Mashabela, Boshomane, Koatale, Mahasha, Ndlovu, Vorster, Rodrigues, Zeevaart, Gordon, Moura-Alves and Sathekge.
PY - 2021/10/8
Y1 - 2021/10/8
N2 - The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID-19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression.
AB - The progression of coronavirus disease 2019 (COVID-19), resulting from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may be influenced by both genetic and environmental factors. Several viruses hijack the host genome machinery for their own advantage and survival, and similar phenomena might occur upon SARS-CoV-2 infection. Severe cases of COVID-19 may be driven by metabolic and epigenetic driven mechanisms, including DNA methylation and histone/chromatin alterations. These epigenetic phenomena may respond to enhanced viral replication and mediate persistent long-term infection and clinical phenotypes associated with severe COVID-19 cases and fatalities. Understanding the epigenetic events involved, and their clinical significance, may provide novel insights valuable for the therapeutic control and management of the COVID-19 pandemic. This review highlights different epigenetic marks potentially associated with COVID-19 development, clinical manifestation, and progression.
KW - ACE2
KW - COVID-19
KW - SARS-CoV-2
KW - TMPRSS2
KW - cytokine storm
KW - epigenetics
KW - multi-organ
KW - pro-inflammatory cytokines
UR - https://www.scopus.com/pages/publications/85117787726
U2 - 10.3389/fimmu.2021.752380
DO - 10.3389/fimmu.2021.752380
M3 - 文献综述
C2 - 34691068
AN - SCOPUS:85117787726
SN - 1664-3224
VL - 12
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 752380
ER -
SDG3 健康與福祉