Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study

L. I. Hsu; K. H. Hsu; H. Y. Chiou; C. J. Chen

doi:10.1201/b20466-171

Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study

L. I. Hsu
, K. H. Hsu
, H. Y. Chiou
, C. J. Chen

Academia Sinica - Genomics Research Center
Chang Gung University
Taipei Medical University

研究成果: 圖書/報告稿件的類型 › 會議稿件 › 同行評審

1 引文斯高帕斯（Scopus）

摘要

The association of arsenic exposure with Chronic Kidney Disease (CKD) has never been reported in low-to-moderate exposed area in Taiwan. The aim of this study is to examine the dose-response relationship between ingested arsenic and CKD in northeastern Taiwan where well arsenic ranged from undetectable to 3590 μg/L. A total of 6,153 participants were followed 1998–2011. The disease status was ascertained through linkage with National Health Insurance database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic exposure. The dose-response relationship between two arsenic exposure indices and CKD was observed. Hazard ratio was 1.00, 0.92 (95% confidence interval (CI), 0.66–1.28), 1.20 (95%CI, 0.90–1.60), 1.46 (95%CI,1.09–1.95), 1.08 (95%CI,0.80– 1.49) and 1.58 (95%CI,1.14–2.18) in relation to well water arsenic concentration of <10.0, 10.0–24.9, 25.0–49.9, 50.0–99.9, 100.0–499.9 and ≥ 500.0 μg/L (P_trend:0.0099). Significantly increased CKD risk was observed among people consuming contaminated water with arsenic concentration >50 μg/L.

原文	英語
主出版物標題	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
編輯	Prosun Bhattacharya, Gunnar Jacks, Jochen Bundschuh, Prosun Bhattacharya, Marie Vahter, Jerker Jarsjo, Jerker Jarsjo, Jurate Kumpiene, Arslan Ahmad, Charlotte Sparrenbom, Marinus Eric Donselaar, Jochen Bundschuh, Ravi Naidu, Ravi Naidu
發行者	CRC Press/Balkema
頁面	361-362
頁數	2
ISBN（列印）	9781138029415
DOIs	https://doi.org/10.1201/b20466-171
出版狀態	已出版 - 2016
對外發佈	是
事件	6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, 瑞典持續時間: 19 06 2016 → 23 06 2016

出版系列

名字	Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

Conference

Conference	6th International Congress on Arsenic in the Environment, AS 2016
國家/地區	瑞典
城市	Stockholm
期間	19/06/16 → 23/06/16

文獻附註

Publisher Copyright:
© 2016 Taylor & Francis Group, London.

UN SDG

此研究成果有助於以下永續發展目標

SDG3 健康與福祉
SDG6 淨水與衛生

存取文件

10.1201/b20466-171

其它文件與鏈接

Link to publication in Scopus

引用此

Hsu, L. I., Hsu, K. H., Chiou, H. Y., & Chen, C. J. (2016). Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. 於 P. Bhattacharya, G. Jacks, J. Bundschuh, P. Bhattacharya, M. Vahter, J. Jarsjo, J. Jarsjo, J. Kumpiene, A. Ahmad, C. Sparrenbom, M. E. Donselaar, J. Bundschuh, R. Naidu, & R. Naidu (編輯), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016 (頁 361-362). (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). CRC Press/Balkema. https://doi.org/10.1201/b20466-171

Hsu, L. I. ; Hsu, K. H. ; Chiou, H. Y. 等. / Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. 編輯 / Prosun Bhattacharya ; Gunnar Jacks ; Jochen Bundschuh ; Prosun Bhattacharya ; Marie Vahter ; Jerker Jarsjo ; Jerker Jarsjo ; Jurate Kumpiene ; Arslan Ahmad ; Charlotte Sparrenbom ; Marinus Eric Donselaar ; Jochen Bundschuh ; Ravi Naidu ; Ravi Naidu. CRC Press/Balkema, 2016. 頁 361-362 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

@inproceedings{d0f3a2860b2e43e19e1eb43b69db1ae2,

title = "Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan{\textemdash}a 14-year perspective study",

abstract = "The association of arsenic exposure with Chronic Kidney Disease (CKD) has never been reported in low-to-moderate exposed area in Taiwan. The aim of this study is to examine the dose-response relationship between ingested arsenic and CKD in northeastern Taiwan where well arsenic ranged from undetectable to 3590 μg/L. A total of 6,153 participants were followed 1998{\textendash}2011. The disease status was ascertained through linkage with National Health Insurance database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic exposure. The dose-response relationship between two arsenic exposure indices and CKD was observed. Hazard ratio was 1.00, 0.92 (95\% confidence interval (CI), 0.66{\textendash}1.28), 1.20 (95\%CI, 0.90{\textendash}1.60), 1.46 (95\%CI,1.09{\textendash}1.95), 1.08 (95\%CI,0.80{\textendash} 1.49) and 1.58 (95\%CI,1.14{\textendash}2.18) in relation to well water arsenic concentration of <10.0, 10.0{\textendash}24.9, 25.0{\textendash}49.9, 50.0{\textendash}99.9, 100.0{\textendash}499.9 and ≥ 500.0 μg/L (Ptrend:0.0099). Significantly increased CKD risk was observed among people consuming contaminated water with arsenic concentration >50 μg/L.",

author = "Hsu, \{L. I.\} and Hsu, \{K. H.\} and Chiou, \{H. Y.\} and Chen, \{C. J.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Taylor \& Francis Group, London.; 6th International Congress on Arsenic in the Environment, AS 2016 ; Conference date: 19-06-2016 Through 23-06-2016",

year = "2016",

doi = "10.1201/b20466-171",

language = "英语",

isbn = "9781138029415",

series = "Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016",

publisher = "CRC Press/Balkema",

pages = "361--362",

editor = "Prosun Bhattacharya and Gunnar Jacks and Jochen Bundschuh and Prosun Bhattacharya and Marie Vahter and Jerker Jarsjo and Jerker Jarsjo and Jurate Kumpiene and Arslan Ahmad and Charlotte Sparrenbom and Donselaar, \{Marinus Eric\} and Jochen Bundschuh and Ravi Naidu and Ravi Naidu",

booktitle = "Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016",

}

Hsu, LI, Hsu, KH, Chiou, HY & Chen, CJ 2016, Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. 於 P Bhattacharya, G Jacks, J Bundschuh, P Bhattacharya, M Vahter, J Jarsjo, J Jarsjo, J Kumpiene, A Ahmad, C Sparrenbom, ME Donselaar, J Bundschuh, R Naidu & R Naidu (編輯), Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016, CRC Press/Balkema, 頁 361-362, 6th International Congress on Arsenic in the Environment, AS 2016, Stockholm, 瑞典, 19/06/16. https://doi.org/10.1201/b20466-171

Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. / Hsu, L. I.; Hsu, K. H.; Chiou, H. Y. 等.
Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. 編輯 / Prosun Bhattacharya; Gunnar Jacks; Jochen Bundschuh; Prosun Bhattacharya; Marie Vahter; Jerker Jarsjo; Jerker Jarsjo; Jurate Kumpiene; Arslan Ahmad; Charlotte Sparrenbom; Marinus Eric Donselaar; Jochen Bundschuh; Ravi Naidu; Ravi Naidu. CRC Press/Balkema, 2016. p. 361-362 (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016).

研究成果: 圖書/報告稿件的類型 › 會議稿件 › 同行評審

TY - GEN

T1 - Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study

AU - Hsu, L. I.

AU - Hsu, K. H.

AU - Chiou, H. Y.

AU - Chen, C. J.

PY - 2016

Y1 - 2016

N2 - The association of arsenic exposure with Chronic Kidney Disease (CKD) has never been reported in low-to-moderate exposed area in Taiwan. The aim of this study is to examine the dose-response relationship between ingested arsenic and CKD in northeastern Taiwan where well arsenic ranged from undetectable to 3590 μg/L. A total of 6,153 participants were followed 1998–2011. The disease status was ascertained through linkage with National Health Insurance database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic exposure. The dose-response relationship between two arsenic exposure indices and CKD was observed. Hazard ratio was 1.00, 0.92 (95% confidence interval (CI), 0.66–1.28), 1.20 (95%CI, 0.90–1.60), 1.46 (95%CI,1.09–1.95), 1.08 (95%CI,0.80– 1.49) and 1.58 (95%CI,1.14–2.18) in relation to well water arsenic concentration of <10.0, 10.0–24.9, 25.0–49.9, 50.0–99.9, 100.0–499.9 and ≥ 500.0 μg/L (Ptrend:0.0099). Significantly increased CKD risk was observed among people consuming contaminated water with arsenic concentration >50 μg/L.

AB - The association of arsenic exposure with Chronic Kidney Disease (CKD) has never been reported in low-to-moderate exposed area in Taiwan. The aim of this study is to examine the dose-response relationship between ingested arsenic and CKD in northeastern Taiwan where well arsenic ranged from undetectable to 3590 μg/L. A total of 6,153 participants were followed 1998–2011. The disease status was ascertained through linkage with National Health Insurance database. Cox regression analysis was used to determine the hazard ratio of the disease associated with arsenic exposure. The dose-response relationship between two arsenic exposure indices and CKD was observed. Hazard ratio was 1.00, 0.92 (95% confidence interval (CI), 0.66–1.28), 1.20 (95%CI, 0.90–1.60), 1.46 (95%CI,1.09–1.95), 1.08 (95%CI,0.80– 1.49) and 1.58 (95%CI,1.14–2.18) in relation to well water arsenic concentration of <10.0, 10.0–24.9, 25.0–49.9, 50.0–99.9, 100.0–499.9 and ≥ 500.0 μg/L (Ptrend:0.0099). Significantly increased CKD risk was observed among people consuming contaminated water with arsenic concentration >50 μg/L.

UR - https://www.scopus.com/pages/publications/85017021887

U2 - 10.1201/b20466-171

DO - 10.1201/b20466-171

M3 - 会议稿件

AN - SCOPUS:85017021887

SN - 9781138029415

T3 - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

SP - 361

EP - 362

BT - Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016

A2 - Bhattacharya, Prosun

A2 - Jacks, Gunnar

A2 - Bundschuh, Jochen

A2 - Bhattacharya, Prosun

A2 - Vahter, Marie

A2 - Jarsjo, Jerker

A2 - Kumpiene, Jurate

A2 - Ahmad, Arslan

A2 - Sparrenbom, Charlotte

A2 - Donselaar, Marinus Eric

A2 - Bundschuh, Jochen

A2 - Naidu, Ravi

PB - CRC Press/Balkema

T2 - 6th International Congress on Arsenic in the Environment, AS 2016

Y2 - 19 June 2016 through 23 June 2016

ER -

Hsu LI, Hsu KH, Chiou HY, Chen CJ. Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study. 於 Bhattacharya P, Jacks G, Bundschuh J, Bhattacharya P, Vahter M, Jarsjo J, Jarsjo J, Kumpiene J, Ahmad A, Sparrenbom C, Donselaar ME, Bundschuh J, Naidu R, Naidu R, 編輯, Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016. CRC Press/Balkema. 2016. p. 361-362. (Arsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016). doi: 10.1201/b20466-171

Dose-response relationship between arsenic exposure from drinking water and chronic kidney disease in low-to-moderate exposed area in taiwan—a 14-year perspective study

摘要

出版系列

Conference

文獻附註

UN SDG

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