Effect of active synthetic 2-substituted quinazolinones on anti-platelet aggregation and the inhibition of superoxide anion generation by neutrophils

Fang Rong Chang, Chin Chung Wu, Tsong Long Hwang, Ramesh Patnam, Reen Yen Kuo, Wei Ya Wang, Yu Hsuan Lan, Yang Chang Wu*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Quinazolinones, 2-substituted and 3-substituted, mainly synthesized by microwave irradiation, were subjected to anti-platelet aggregation and inhibition of superoxide anion generation assays. Interestingly, 2-phenyl-4-quinazolinone (4) exhibited significant inhibitory activities toward platelet aggregation and neutrophil activation, and it might therefore serve as a prototype lead compound.

原文英語
頁(從 - 到)511-515
頁數5
期刊Archives of Pharmacal Research
26
發行號7
DOIs
出版狀態已出版 - 30 07 2003

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