Effect of solvent on enantioselective esterification of naproxen by lipase with trimethylsilyl methanol

Shau‐Wei ‐W Tsai; Hwa‐Jou ‐J Wei

doi:10.1002/bit.260430109

Effect of solvent on enantioselective esterification of naproxen by lipase with trimethylsilyl methanol

Shau‐Wei ‐W Tsai^*
, Hwa‐Jou ‐J Wei

^*此作品的通信作者

National Cheng Kung University

研究成果: 期刊稿件 › 文章 › 同行評審

28 引文斯高帕斯（Scopus）

摘要

Improvement of stereoselective resolution of racemic Naproxen, 2‐(6‐methoxy‐2‐naphthyl)propionic acid, was attempted with esterifcation reaction by Candida cylindracea lipase. By carefully selecting the organic medium, a 72‐time enhancement of yield of the desired S‐ester was achieved. The optimal reaction temperature was approximately 53°C, and an alcohol concentration between 20 mM and 40 mM in an 80% (v/v) isooctane and 20% (v/v) toluene mixture was found. © 1994 John Wiley & Sons, Inc.

原文	英語
頁（從 - 到）	64-68
頁數	5
期刊	Biotechnology and Bioengineering
卷	43
發行號	1
DOIs	https://doi.org/10.1002/bit.260430109
出版狀態	已出版 - 05 01 1994
對外發佈	是

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title = "Effect of solvent on enantioselective esterification of naproxen by lipase with trimethylsilyl methanol",

abstract = "Improvement of stereoselective resolution of racemic Naproxen, 2‐(6‐methoxy‐2‐naphthyl)propionic acid, was attempted with esterifcation reaction by Candida cylindracea lipase. By carefully selecting the organic medium, a 72‐time enhancement of yield of the desired S‐ester was achieved. The optimal reaction temperature was approximately 53°C, and an alcohol concentration between 20 mM and 40 mM in an 80\% (v/v) isooctane and 20\% (v/v) toluene mixture was found. {\textcopyright} 1994 John Wiley \& Sons, Inc.",

keywords = "Naproxen, enantioselectivity, esterification, lipase",

author = "Tsai, \{Shau‐Wei ‐W\} and Wei, \{Hwa‐Jou ‐J\}",

year = "1994",

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doi = "10.1002/bit.260430109",

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AU - Tsai, Shau‐Wei ‐W

AU - Wei, Hwa‐Jou ‐J

PY - 1994/1/5

Y1 - 1994/1/5

N2 - Improvement of stereoselective resolution of racemic Naproxen, 2‐(6‐methoxy‐2‐naphthyl)propionic acid, was attempted with esterifcation reaction by Candida cylindracea lipase. By carefully selecting the organic medium, a 72‐time enhancement of yield of the desired S‐ester was achieved. The optimal reaction temperature was approximately 53°C, and an alcohol concentration between 20 mM and 40 mM in an 80% (v/v) isooctane and 20% (v/v) toluene mixture was found. © 1994 John Wiley & Sons, Inc.

AB - Improvement of stereoselective resolution of racemic Naproxen, 2‐(6‐methoxy‐2‐naphthyl)propionic acid, was attempted with esterifcation reaction by Candida cylindracea lipase. By carefully selecting the organic medium, a 72‐time enhancement of yield of the desired S‐ester was achieved. The optimal reaction temperature was approximately 53°C, and an alcohol concentration between 20 mM and 40 mM in an 80% (v/v) isooctane and 20% (v/v) toluene mixture was found. © 1994 John Wiley & Sons, Inc.

KW - Naproxen

KW - enantioselectivity

KW - esterification

KW - lipase

UR - https://www.scopus.com/pages/publications/0028764609

U2 - 10.1002/bit.260430109

DO - 10.1002/bit.260430109

M3 - 文章

AN - SCOPUS:0028764609

SN - 0006-3592

VL - 43

SP - 64

EP - 68

JO - Biotechnology and Bioengineering

JF - Biotechnology and Bioengineering

IS - 1

ER -

Effect of solvent on enantioselective esterification of naproxen by lipase with trimethylsilyl methanol

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