Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: A pilot study

Kang Hsi Wu; Tefu Weng; Han Ping Wu; Ching Tien Peng; Ji Nan Sheu; Yu Hua Chao

doi:10.1097/INF.0000000000000407

Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: A pilot study

Kang Hsi Wu, Tefu Weng, Han Ping Wu, Ching Tien Peng, Ji Nan Sheu, Yu Hua Chao^*

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

17 引文斯高帕斯（Scopus）

摘要

Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).

原文	英語
頁（從 - 到）	1193-1195
頁數	3
期刊	Pediatric Infectious Disease Journal
卷	33
發行號	11
DOIs	https://doi.org/10.1097/INF.0000000000000407
出版狀態	已出版 - 2014
對外發佈	是

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Copyright © 2014 by Lippincott Williams & Wilkins.

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title = "Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: A pilot study",

abstract = "Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).",

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author = "Wu, {Kang Hsi} and Tefu Weng and Wu, {Han Ping} and Peng, {Ching Tien} and Sheu, {Ji Nan} and Chao, {Yu Hua}",

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T2 - A pilot study

AU - Wu, Kang Hsi

AU - Weng, Tefu

AU - Wu, Han Ping

AU - Peng, Ching Tien

AU - Sheu, Ji Nan

AU - Chao, Yu Hua

PY - 2014

Y1 - 2014

N2 - Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).

AB - Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).

KW - BK virus

KW - Hematopoietic stem cell transplantation

KW - Hemorrhagic cystitis

KW - Lefunomide

KW - Pediatrics

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SN - 0891-3668

VL - 33

SP - 1193

EP - 1195

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 11

ER -

Effective treatment of severe BK virus-associated hemorrhagic cystitis with leflunomide in children after hematopoietic stem cell transplantation: A pilot study

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