Enantioselective synthesis of (s)-ibuprofen ester prodrug in cyclohexane by Candida rugosa lipase immobilized on Accurel MP1000

J. C. Chen, S. W. Tsai*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

62 引文 斯高帕斯(Scopus)

摘要

An enantioselective esterification process was developed for the synthesis of 2-N-morpholinoethyl (S)-ibuprofen ester prodrug from racemic ibuprofen by using Candida rugosa lipase immobilized on Accurel MP1000 in cyclohexane. Compared with the performance of Lipase MY, the immobilized lipase possesses a higher enzyme activity and thermal stability, but with a slightly suppressed enantioselectivity. A kinetic model was proposed and confirmed from experiments, for the simulation of time-course conversions of both enantiomers at various combinations of substrate concentrations in a batch reactor. Preliminary results of employing the proposed model and the immobilized lipase in a continuous packed-bed reactor were also reported and discussed.

原文英語
頁(從 - 到)986-992
頁數7
期刊Biotechnology Progress
16
發行號6
DOIs
出版狀態已出版 - 2000
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