摘要
An enantioselective esterification process was developed for the synthesis of 2-N-morpholinoethyl (S)-ibuprofen ester prodrug from racemic ibuprofen by using Candida rugosa lipase immobilized on Accurel MP1000 in cyclohexane. Compared with the performance of Lipase MY, the immobilized lipase possesses a higher enzyme activity and thermal stability, but with a slightly suppressed enantioselectivity. A kinetic model was proposed and confirmed from experiments, for the simulation of time-course conversions of both enantiomers at various combinations of substrate concentrations in a batch reactor. Preliminary results of employing the proposed model and the immobilized lipase in a continuous packed-bed reactor were also reported and discussed.
原文 | 英語 |
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頁(從 - 到) | 986-992 |
頁數 | 7 |
期刊 | Biotechnology Progress |
卷 | 16 |
發行號 | 6 |
DOIs | |
出版狀態 | 已出版 - 2000 |
對外發佈 | 是 |