Eunicellin-based diterpenoids from the formosan soft coral klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils

Ming Chang Lin, Bo Wei Chen, Chiung Yao Huang, Chang Feng Dai, Tsong Long Hwang, Jyh Horng Sheu*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

35 引文 斯高帕斯(Scopus)

摘要

Eleven new eunicellin-based diterpenoids possessing a cladiellane skeleton with a C-2, C-9 ether bridge, klymollins I-S (1-11), have been isolated from the EtOAc extract of the soft coral Klyxum molle from Taiwan waters. The structures of compounds 1-11 were elucidated by extensive spectroscopic analysis, including 2D NMR spectroscopy (COSY, HSQC, HMBC, and NOESY). Compound 5 exhibited cytotoxicity toward several cancer cell lines. Compound 5 is the first eunicellin-based metabolite bearing a phenyl group and displays significant inhibition of both superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced human neutrophils.

原文英語
頁(從 - 到)1661-1667
頁數7
期刊Journal of Natural Products
76
發行號9
DOIs
出版狀態已出版 - 27 09 2013

指紋

深入研究「Eunicellin-based diterpenoids from the formosan soft coral klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils」主題。共同形成了獨特的指紋。

引用此