Extracellular vesicles of adipose‐derived stem cells promote the healing of traumatized achilles tendons

Shih Heng Chen, Zhi Yu Chen, Ya Hsuan Lin, Shih Hsien Chen, Pang Yun Chou, Huang Kai Kao*, Feng Huei Lin*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

32 引文 斯高帕斯(Scopus)

摘要

Healing of ruptured tendons remains a clinical challenge because of its slow progress and relatively weak mechanical force at an early stage. Extracellular vesicles (EVs) derived from mesen-chymal stem cells (MSCs) have therapeutic potential for tissue regeneration. In this study, we isolated EVs from adipose‐derived stem cells (ADSCs) and evaluated their ability to promote tendon regeneration. Our results indicated that ADSC‐EVs significantly enhanced the proliferation and migration of tenocytes in vitro. To further study the roles of ADSC‐EVs in tendon regeneration, ADSC‐ EVs were used in Achilles tendon repair in rabbits. The mechanical strength, histology, and protein expression in the injured tendon tissues significantly improved 4 weeks after ADSC‐EV treatment. Decorin and biglycan were significantly upregulated in comparison to the untreated controls. In summary, ADSC‐EVs stimulated the proliferation and migration of tenocytes and improved the mechanical strength of repaired tendons, suggesting that ADSC‐EV treatment is a potential highly potent therapeutic strategy for tendon injuries.

原文英語
文章編號12373
期刊International Journal of Molecular Sciences
22
發行號22
DOIs
出版狀態已出版 - 01 11 2021

文獻附註

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

指紋

深入研究「Extracellular vesicles of adipose‐derived stem cells promote the healing of traumatized achilles tendons」主題。共同形成了獨特的指紋。

引用此