Factors influencing neutralizing antibody titers elicited by coronavirus disease 2019 vaccines

Yu An Kung; Sheng Yu Huang; Chung Guei Huang; Kuan Ting Liu; Peng Nien Huang; Kar Yee Yu; Shu Li Yang; Chia Pei Chen; Ching Yun Cheng; Ing Kit Lee; Shu Min Lin; Han Pin Chang; Yueh Te Lin; Yen Chin Liu; Guang Wu Chen; Shin Ru Shih

doi:10.1016/j.micinf.2022.105044

Factors influencing neutralizing antibody titers elicited by coronavirus disease 2019 vaccines

Yu An Kung, Sheng Yu Huang, Chung Guei Huang, Kuan Ting Liu, Peng Nien Huang, Kar Yee Yu, Shu Li Yang, Chia Pei Chen, Ching Yun Cheng, Ing Kit Lee, Shu Min Lin, Han Pin Chang, Yueh Te Lin, Yen Chin Liu, Guang Wu Chen^*, Shin Ru Shih^*

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

8 引文斯高帕斯（Scopus）

摘要

The World Health Organization has highlighted the importance of an international standard (IS) for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) neutralizing antibody titer detection to calibrate diagnostic techniques. We applied an IS to calibrate neutralizing antibody titers (NTs) (international units/mL) in response to coronavirus disease 2019 (COVID-19) vaccination. Moreover, the association between different factors and neutralizing antibodies was analyzed. A total of 1667 serum samples were collected from participants receiving different COVID-19 vaccines. Antibody titers were determined by a microneutralization assay using live viruses in a biosafety level 3 (BSL-3) laboratory and a commercial serological MeDiPro kit. The titer determined using the MeDiPro kit was highly correlated with the NT determined using live viruses and calibrated using IS. Fever and antipyretic analgesic treatment were related to neutralizing antibody responses in ChAdOx1-S and BNT162b2 vaccinations. Individuals with diabetes showed a low NT elicited by MVC-COV1901. Individuals with hypertension receiving the BNT162b2 vaccine had lower NTs than those without hypertension. Our study provided the international unit (IU) values of NTs in vaccinated individuals for the development of vaccines and implementation of non-inferiority trials. Correlation of the influencing factors with NTs can provide an indicator for selecting COVID-19 vaccines based on personal attributes.

原文	英語
文章編號	105044
頁（從 - 到）	105044
期刊	Microbes and Infection
卷	25
發行號	1-2
DOIs	https://doi.org/10.1016/j.micinf.2022.105044
出版狀態	已出版 - 01 01 2023

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Kung, Y. A., Huang, S. Y., Huang, C. G., Liu, K. T., Huang, P. N., Yu, K. Y., Yang, S. L., Chen, C. P., Cheng, C. Y., Lee, I. K., Lin, S. M., Chang, H. P., Lin, Y. T., Liu, Y. C., Chen, G. W., & Shih, S. R. (2023). Factors influencing neutralizing antibody titers elicited by coronavirus disease 2019 vaccines. Microbes and Infection, 25(1-2), 105044. 文章 105044. https://doi.org/10.1016/j.micinf.2022.105044

@article{fc713e436fce45e78ce066cb2e2324c0,

title = "Factors influencing neutralizing antibody titers elicited by coronavirus disease 2019 vaccines",

abstract = "The World Health Organization has highlighted the importance of an international standard (IS) for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) neutralizing antibody titer detection to calibrate diagnostic techniques. We applied an IS to calibrate neutralizing antibody titers (NTs) (international units/mL) in response to coronavirus disease 2019 (COVID-19) vaccination. Moreover, the association between different factors and neutralizing antibodies was analyzed. A total of 1667 serum samples were collected from participants receiving different COVID-19 vaccines. Antibody titers were determined by a microneutralization assay using live viruses in a biosafety level 3 (BSL-3) laboratory and a commercial serological MeDiPro kit. The titer determined using the MeDiPro kit was highly correlated with the NT determined using live viruses and calibrated using IS. Fever and antipyretic analgesic treatment were related to neutralizing antibody responses in ChAdOx1-S and BNT162b2 vaccinations. Individuals with diabetes showed a low NT elicited by MVC-COV1901. Individuals with hypertension receiving the BNT162b2 vaccine had lower NTs than those without hypertension. Our study provided the international unit (IU) values of NTs in vaccinated individuals for the development of vaccines and implementation of non-inferiority trials. Correlation of the influencing factors with NTs can provide an indicator for selecting COVID-19 vaccines based on personal attributes.",

keywords = "COVID-19 vaccines, International standard, Neutralizing antibody titers, Antibodies, Neutralizing, Hypertension, BNT162 Vaccine, SARS-CoV-2, Humans, COVID-19 Vaccines, Vaccination, COVID-19/prevention & control, Antibodies, Viral",

author = "Kung, {Yu An} and Huang, {Sheng Yu} and Huang, {Chung Guei} and Liu, {Kuan Ting} and Huang, {Peng Nien} and Yu, {Kar Yee} and Yang, {Shu Li} and Chen, {Chia Pei} and Cheng, {Ching Yun} and Lee, {Ing Kit} and Lin, {Shu Min} and Chang, {Han Pin} and Lin, {Yueh Te} and Liu, {Yen Chin} and Chen, {Guang Wu} and Shih, {Shin Ru}",

note = "Copyright {\textcopyright} 2022. Published by Elsevier Masson SAS.",

year = "2023",

month = jan,

day = "1",

doi = "10.1016/j.micinf.2022.105044",

language = "英语",

volume = "25",

pages = "105044",

journal = "Microbes and Infection",

issn = "1286-4579",

publisher = "Elsevier Masson s.r.l.",

number = "1-2",

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Kung, YA, Huang, SY, Huang, CG, Liu, KT, Huang, PN, Yu, KY, Yang, SL, Chen, CP, Cheng, CY, Lee, IK, Lin, SM, Chang, HP, Lin, YT, Liu, YC , Chen, GW & Shih, SR 2023, 'Factors influencing neutralizing antibody titers elicited by coronavirus disease 2019 vaccines', Microbes and Infection, 卷 25, 編號 1-2, 105044, 頁 105044. https://doi.org/10.1016/j.micinf.2022.105044

TY - JOUR

T1 - Factors influencing neutralizing antibody titers elicited by coronavirus disease 2019 vaccines

AU - Kung, Yu An

AU - Huang, Sheng Yu

AU - Huang, Chung Guei

AU - Liu, Kuan Ting

AU - Huang, Peng Nien

AU - Yu, Kar Yee

AU - Yang, Shu Li

AU - Chen, Chia Pei

AU - Cheng, Ching Yun

AU - Lee, Ing Kit

AU - Lin, Shu Min

AU - Chang, Han Pin

AU - Lin, Yueh Te

AU - Liu, Yen Chin

AU - Chen, Guang Wu

AU - Shih, Shin Ru

PY - 2023/1/1

Y1 - 2023/1/1

N2 - The World Health Organization has highlighted the importance of an international standard (IS) for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) neutralizing antibody titer detection to calibrate diagnostic techniques. We applied an IS to calibrate neutralizing antibody titers (NTs) (international units/mL) in response to coronavirus disease 2019 (COVID-19) vaccination. Moreover, the association between different factors and neutralizing antibodies was analyzed. A total of 1667 serum samples were collected from participants receiving different COVID-19 vaccines. Antibody titers were determined by a microneutralization assay using live viruses in a biosafety level 3 (BSL-3) laboratory and a commercial serological MeDiPro kit. The titer determined using the MeDiPro kit was highly correlated with the NT determined using live viruses and calibrated using IS. Fever and antipyretic analgesic treatment were related to neutralizing antibody responses in ChAdOx1-S and BNT162b2 vaccinations. Individuals with diabetes showed a low NT elicited by MVC-COV1901. Individuals with hypertension receiving the BNT162b2 vaccine had lower NTs than those without hypertension. Our study provided the international unit (IU) values of NTs in vaccinated individuals for the development of vaccines and implementation of non-inferiority trials. Correlation of the influencing factors with NTs can provide an indicator for selecting COVID-19 vaccines based on personal attributes.

AB - The World Health Organization has highlighted the importance of an international standard (IS) for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) neutralizing antibody titer detection to calibrate diagnostic techniques. We applied an IS to calibrate neutralizing antibody titers (NTs) (international units/mL) in response to coronavirus disease 2019 (COVID-19) vaccination. Moreover, the association between different factors and neutralizing antibodies was analyzed. A total of 1667 serum samples were collected from participants receiving different COVID-19 vaccines. Antibody titers were determined by a microneutralization assay using live viruses in a biosafety level 3 (BSL-3) laboratory and a commercial serological MeDiPro kit. The titer determined using the MeDiPro kit was highly correlated with the NT determined using live viruses and calibrated using IS. Fever and antipyretic analgesic treatment were related to neutralizing antibody responses in ChAdOx1-S and BNT162b2 vaccinations. Individuals with diabetes showed a low NT elicited by MVC-COV1901. Individuals with hypertension receiving the BNT162b2 vaccine had lower NTs than those without hypertension. Our study provided the international unit (IU) values of NTs in vaccinated individuals for the development of vaccines and implementation of non-inferiority trials. Correlation of the influencing factors with NTs can provide an indicator for selecting COVID-19 vaccines based on personal attributes.

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KW - International standard

KW - Neutralizing antibody titers

KW - Antibodies, Neutralizing

KW - Hypertension

KW - BNT162 Vaccine

KW - SARS-CoV-2

KW - Humans

KW - COVID-19 Vaccines

KW - Vaccination

KW - COVID-19/prevention & control

KW - Antibodies, Viral

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U2 - 10.1016/j.micinf.2022.105044

DO - 10.1016/j.micinf.2022.105044

M3 - 文章

C2 - 36096357

AN - SCOPUS:85143990224

SN - 1286-4579

VL - 25

SP - 105044

JO - Microbes and Infection

JF - Microbes and Infection

IS - 1-2

M1 - 105044

ER -

Factors influencing neutralizing antibody titers elicited by coronavirus disease 2019 vaccines

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