TY - JOUR
T1 - Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples
AU - Xu, Xiaohui
AU - Mill, Jonathan
AU - Zhou, Kaixin
AU - Brookes, Keeley
AU - Chen, Chih Ken
AU - Asherson, Philip
PY - 2007/1/5
Y1 - 2007/1/5
N2 - Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: χx2 = 6.78, P = 0.009) and the two samples pooled together (TDT: χx2 = 7.24, P = 0.007). No association was found between the Val66Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Val66 allele and the 270T allele in the Taiwanese samples (TDT: χx2 = 4.57, P = 0.032) and the pooled sample set (TDT: χx2 = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD.
AB - Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Val66Met, C270T) in two samples of ADHD probands from the United Kingdom (n = 180) and Taiwan (n = 212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: χx2 = 6.78, P = 0.009) and the two samples pooled together (TDT: χx2 = 7.24, P = 0.007). No association was found between the Val66Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Val66 allele and the 270T allele in the Taiwanese samples (TDT: χx2 = 4.57, P = 0.032) and the pooled sample set (TDT: χx2 = 5.82, P = 0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD.
KW - Association studies
KW - Attention-deficit hyperactivity disorder (ADHD)
KW - Brain-derived neurotrophic factor (BDNF)
KW - Single nucleotide polymorphism (SNP)
UR - https://www.scopus.com/pages/publications/33846319729
U2 - 10.1002/ajmg.b.30406
DO - 10.1002/ajmg.b.30406
M3 - 文章
C2 - 17044097
AN - SCOPUS:33846319729
SN - 1552-4841
VL - 144
SP - 83
EP - 86
JO - American Journal of Medical Genetics - Neuropsychiatric Genetics
JF - American Journal of Medical Genetics - Neuropsychiatric Genetics
IS - 1
ER -