Ferritin RNA interference inhibits the formation of iron granules in the trophocytes of worker honey bees (Apis mellifera)

Chin Yuan Hsu*, Hsiao Fan Lo, Navdeep S. Mutti, Gro V. Amdam

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Iron granules containing superparamagnetic magnetite act as magnetoreceptor for magnetoreception in honey bees. Biomineralization of iron granules occurs in the iron deposition vesicles of trophocytes and requires the participation of actin, myosin, ferritin2, and ATP synthase. The mechanism of magnetoreception in honey bees can be explored by suppressing the formation of iron granules. Toward this goal, we injected double-stranded RNA of ferritin2 and ferritin1 into newly emerged worker honey bees to knock down these genes via RNA interference. We confirmed that mRNA and protein production of the ferritins was inhibited, leading to immature iron granules. Downregulating ferritin2 and ferritin1, moreover, leads to different deposition morphology of 7.5-nm diameter iron particles, indicating that the two genes play different roles in the formation of iron granules in worker honey bees.

原文英語
文章編號10098
期刊Scientific Reports
9
發行號1
DOIs
出版狀態已出版 - 01 12 2019

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© 2019, The Author(s).

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