TY - JOUR
T1 - Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity
AU - Chakraborty, Srishti
AU - Debnath, Souvik
AU - Mahipal Malappuram, Kailas
AU - Parasuram, Sampath
AU - Chang, Huan Tsung
AU - Chatterjee, Kaushik
AU - Nain, Amit
N1 - Publisher Copyright:
© 2025 American Chemical Society.
PY - 2025/2/10
Y1 - 2025/2/10
N2 - Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage is limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via a solvent casting method and cross-linked in an alkaline solution. Sodium hydroxide facilitated deprotonation, leading to increased intramolecular hydrogen bonding and mechanical properties. The CHT film remained intact for 30 days in aqueous environments. A systematic study revealed a gradual increase in the output voltage from 0.9 to 1.8 V under external force (1-16 N). In addition, the CHT film showed remarkable antibacterial and anti-inflammatory activities under ultrasound stimulation and inhibition of inflammatory cytokines. The CHT films also displayed enhanced cellular proliferation and ∼5-fold faster migration of NIH3T3 cells under US stimulation. Overall, this work presents a robust, biocompatible, and wearable CHT device that can transform biomechanical energy into electrical pulses for the modulation of cell fate processes and other bioactivities.
AB - Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage is limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via a solvent casting method and cross-linked in an alkaline solution. Sodium hydroxide facilitated deprotonation, leading to increased intramolecular hydrogen bonding and mechanical properties. The CHT film remained intact for 30 days in aqueous environments. A systematic study revealed a gradual increase in the output voltage from 0.9 to 1.8 V under external force (1-16 N). In addition, the CHT film showed remarkable antibacterial and anti-inflammatory activities under ultrasound stimulation and inhibition of inflammatory cytokines. The CHT films also displayed enhanced cellular proliferation and ∼5-fold faster migration of NIH3T3 cells under US stimulation. Overall, this work presents a robust, biocompatible, and wearable CHT device that can transform biomechanical energy into electrical pulses for the modulation of cell fate processes and other bioactivities.
KW - Chitosan/chemistry
KW - Mice
KW - Animals
KW - NIH 3T3 Cells
KW - Anti-Bacterial Agents/pharmacology
KW - Biocompatible Materials/chemistry
KW - Cell Proliferation/drug effects
KW - Anti-Inflammatory Agents/pharmacology
KW - Cell Movement/drug effects
UR - https://www.scopus.com/pages/publications/85215660143
U2 - 10.1021/acs.biomac.4c01464
DO - 10.1021/acs.biomac.4c01464
M3 - 文章
C2 - 39804579
AN - SCOPUS:85215660143
SN - 1525-7797
VL - 26
SP - 1128
EP - 1140
JO - Biomacromolecules
JF - Biomacromolecules
IS - 2
ER -