Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene

Yu Hung Hsu; Yu Ting Wu; Ching Ying Huang; Ming Ching Ho; Yu Che Cheng; Shih Han Syu; Huai En Lu; Yen Chun Chen; Chia Ling Tsai; Hung Ching Lin; Yau Huei Wei; Yi Chao Hsu; Patrick C.H. Hsieh

doi:10.1016/j.scr.2017.10.024

Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene

Yu Hung Hsu
, Yu Ting Wu
, Ching Ying Huang
, Ming Ching Ho
, Yu Che Cheng
, Shih Han Syu
, Huai En Lu
, Yen Chun Chen
, Chia Ling Tsai
, Hung Ching Lin
, Yau Huei Wei
, Yi Chao Hsu
, Patrick C.H. Hsieh^*

^*此作品的通信作者

Academia Sinica - Institute of Biomedical Sciences
Changhua Christian Hospital
Food Industry Research and Development Institute
Mackay Memorial Hospital Taiwan

研究成果: 期刊稿件 › 文章 › 同行評審

9 引文斯高帕斯（Scopus）

摘要

Sensorineural hearing loss (SNHL) is a prevalent form of deafness commonly arising from damage to the cochlear sensory hair cells and degeneration of the spiral ganglion neurons. In this study, Sendai virus was used to generate an induced pluripotent stem cell (iPSC) line from a 39-year-old female patient diagnosed with severe-to-profound, non-syndromic SNHL. The patient also carries a A1555G mutation in the mitochondrial 12S ribosome RNA gene (MTRNR1). This iPSC line was verified to express pluripotent markers, possess normal karyotype, harbor the specific mutation and demonstrated the capacity to differentiate into three germ layers.

原文	英語
頁（從 - 到）	245-249
頁數	5
期刊	Stem Cell Research
卷	25
DOIs	https://doi.org/10.1016/j.scr.2017.10.024
出版狀態	已出版 - 12 2017
對外發佈	是

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Hsu, Y. H., Wu, Y. T., Huang, C. Y., Ho, M. C., Cheng, Y. C., Syu, S. H., Lu, H. E., Chen, Y. C., Tsai, C. L., Lin, H. C., Wei, Y. H., Hsu, Y. C., & Hsieh, P. C. H. (2017). Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene. Stem Cell Research, 25, 245-249. https://doi.org/10.1016/j.scr.2017.10.024

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title = "Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene",

abstract = "Sensorineural hearing loss (SNHL) is a prevalent form of deafness commonly arising from damage to the cochlear sensory hair cells and degeneration of the spiral ganglion neurons. In this study, Sendai virus was used to generate an induced pluripotent stem cell (iPSC) line from a 39-year-old female patient diagnosed with severe-to-profound, non-syndromic SNHL. The patient also carries a A1555G mutation in the mitochondrial 12S ribosome RNA gene (MTRNR1). This iPSC line was verified to express pluripotent markers, possess normal karyotype, harbor the specific mutation and demonstrated the capacity to differentiate into three germ layers.",

author = "Hsu, \{Yu Hung\} and Wu, \{Yu Ting\} and Huang, \{Ching Ying\} and Ho, \{Ming Ching\} and Cheng, \{Yu Che\} and Syu, \{Shih Han\} and Lu, \{Huai En\} and Chen, \{Yen Chun\} and Tsai, \{Chia Ling\} and Lin, \{Hung Ching\} and Wei, \{Yau Huei\} and Hsu, \{Yi Chao\} and Hsieh, \{Patrick C.H.\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors",

year = "2017",

month = dec,

doi = "10.1016/j.scr.2017.10.024",

language = "英语",

volume = "25",

pages = "245--249",

journal = "Stem Cell Research",

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}

Hsu, YH, Wu, YT, Huang, CY, Ho, MC, Cheng, YC, Syu, SH, Lu, HE, Chen, YC, Tsai, CL, Lin, HC, Wei, YH, Hsu, YC & Hsieh, PCH 2017, 'Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene', Stem Cell Research, 卷 25, 頁 245-249. https://doi.org/10.1016/j.scr.2017.10.024

TY - JOUR

T1 - Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene

AU - Hsu, Yu Hung

AU - Wu, Yu Ting

AU - Huang, Ching Ying

AU - Ho, Ming Ching

AU - Cheng, Yu Che

AU - Syu, Shih Han

AU - Lu, Huai En

AU - Chen, Yen Chun

AU - Tsai, Chia Ling

AU - Lin, Hung Ching

AU - Wei, Yau Huei

AU - Hsu, Yi Chao

AU - Hsieh, Patrick C.H.

PY - 2017/12

Y1 - 2017/12

N2 - Sensorineural hearing loss (SNHL) is a prevalent form of deafness commonly arising from damage to the cochlear sensory hair cells and degeneration of the spiral ganglion neurons. In this study, Sendai virus was used to generate an induced pluripotent stem cell (iPSC) line from a 39-year-old female patient diagnosed with severe-to-profound, non-syndromic SNHL. The patient also carries a A1555G mutation in the mitochondrial 12S ribosome RNA gene (MTRNR1). This iPSC line was verified to express pluripotent markers, possess normal karyotype, harbor the specific mutation and demonstrated the capacity to differentiate into three germ layers.

AB - Sensorineural hearing loss (SNHL) is a prevalent form of deafness commonly arising from damage to the cochlear sensory hair cells and degeneration of the spiral ganglion neurons. In this study, Sendai virus was used to generate an induced pluripotent stem cell (iPSC) line from a 39-year-old female patient diagnosed with severe-to-profound, non-syndromic SNHL. The patient also carries a A1555G mutation in the mitochondrial 12S ribosome RNA gene (MTRNR1). This iPSC line was verified to express pluripotent markers, possess normal karyotype, harbor the specific mutation and demonstrated the capacity to differentiate into three germ layers.

UR - https://www.scopus.com/pages/publications/85034826039

U2 - 10.1016/j.scr.2017.10.024

DO - 10.1016/j.scr.2017.10.024

M3 - 文章

C2 - 29174977

AN - SCOPUS:85034826039

SN - 1873-5061

VL - 25

SP - 245

EP - 249

JO - Stem Cell Research

JF - Stem Cell Research

ER -

Generation of an induced pluripotent stem cell line from a 39-year-old female patient with severe-to-profound non-syndromic sensorineural hearing loss and a A1555G mutation in the mitochondrial MTRNR1 gene

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