Genetic and environmental impacts on DNA methylation levels in twins

Idil Yet, Pei Chien Tsai, Juan E. Castillo-Fernandez, Elena Carnero-Montoro, Jordana T. Bell*

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

25 引文 斯高帕斯(Scopus)

摘要

Epigenetics describes the study of cellular modifications that can modify the expression of genes without changing the DNA sequence. DNA methylation is one of the most stable and prevalent epigenetic mechanisms. Twin studies have been a valuable model for unraveling the genetic and epigenetic epidemiology of complex traits, and now offer a potential to dissect the factors that impact DNA methylation variability and its biomedical significance. The twin design specifically allows for the study of genetic, environmental and lifestyle factors, and their potential interactions, on epigenetic profiles. Furthermore, genetically identical twins offer a unique opportunity to assess nongenetic impacts on epigenetic profiles. Here, we summarize recent findings from twin studies of DNA methylation profiles across tissues, to define current knowledge regarding the genetic and nongenetic factors that influence epigenetic variation.

原文英語
頁(從 - 到)105-117
頁數13
期刊Epigenomics
8
發行號1
DOIs
出版狀態已出版 - 01 2016
對外發佈

文獻附註

Publisher Copyright:
© 2016 Future Medicine Ltd.

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