Gold nanoparticles presenting hybridized self-assembled aptamers that exhibit enhanced inhibition of thrombin

Yen Chun Shiang; Chia Lun Hsu; Chih Ching Huang; Huan Tsung Chang

doi:10.1002/anie.201101718

Gold nanoparticles presenting hybridized self-assembled aptamers that exhibit enhanced inhibition of thrombin

Yen Chun Shiang^*
, Chia Lun Hsu
, Chih Ching Huang
, Huan Tsung Chang

^*此作品的通信作者

National Taiwan University
National Taiwan Ocean University

研究成果: 期刊稿件 › 文章 › 同行評審

43 引文斯高帕斯（Scopus）

摘要

DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (AuNPs) was used to control the coagulation activity of thrombin. The hTBA ₁₅/hTBA ₂₉/cDNA-AuNPs provided flexibility and a suitable orientation and distance between the hTBA ₁₅ and hTBA ₂₉ units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.

原文	英語
頁（從 - 到）	7660-7665
頁數	6
期刊	Angewandte Chemie - International Edition
卷	50
發行號	33
DOIs	https://doi.org/10.1002/anie.201101718
出版狀態	已出版 - 08 08 2011
對外發佈	是

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abstract = "DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (AuNPs) was used to control the coagulation activity of thrombin. The hTBA 15/hTBA 29/cDNA-AuNPs provided flexibility and a suitable orientation and distance between the hTBA 15 and hTBA 29 units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.",

keywords = "aptamers, enzyme activity, gold, nanoparticles, thrombin",

author = "Shiang, \{Yen Chun\} and Hsu, \{Chia Lun\} and Huang, \{Chih Ching\} and Chang, \{Huan Tsung\}",

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AU - Shiang, Yen Chun

AU - Hsu, Chia Lun

AU - Huang, Chih Ching

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PY - 2011/8/8

Y1 - 2011/8/8

N2 - DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (AuNPs) was used to control the coagulation activity of thrombin. The hTBA 15/hTBA 29/cDNA-AuNPs provided flexibility and a suitable orientation and distance between the hTBA 15 and hTBA 29 units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.

AB - DNA hybridization of thrombin-binding aptamers (TBAs) to form a self-assembled arranged monolayer on gold nanoparticles (AuNPs) was used to control the coagulation activity of thrombin. The hTBA 15/hTBA 29/cDNA-AuNPs provided flexibility and a suitable orientation and distance between the hTBA 15 and hTBA 29 units for bivalent binding, allowing strong interactions with thrombin and extremely high anticoagulant potency.

KW - aptamers

KW - enzyme activity

KW - gold

KW - nanoparticles

KW - thrombin

UR - https://www.scopus.com/pages/publications/79961224814

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DO - 10.1002/anie.201101718

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AN - SCOPUS:79961224814

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 33

ER -

Gold nanoparticles presenting hybridized self-assembled aptamers that exhibit enhanced inhibition of thrombin

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