G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

Ying Ju Lin; Lei Wan; Jim Jinn Chyuan Sheu; Chung Ming Huang; Cheng Wen Lin; Yu Ching Lan; Chih Ho Lai; Chien Hui Hung; Yuhsin Tsai; Chang Hai Tsai; Wei Yong Lin; Hsin Ping Liu; Ting Hsu Lin; Yu Min Huang; Fuu Jen Tsai

doi:10.1016/j.clim.2008.05.011

G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

Ying Ju Lin
, Lei Wan
, Jim Jinn Chyuan Sheu
, Chung Ming Huang
, Cheng Wen Lin
, Yu Ching Lan
, Chih Ho Lai
, Chien Hui Hung
, Yuhsin Tsai
, Chang Hai Tsai
, Wei Yong Lin
, Hsin Ping Liu
, Ting Hsu Lin
, Yu Min Huang
, Fuu Jen Tsai^*

^*此作品的通信作者

研究成果: 期刊稿件 › 文章 › 同行評審

13 引文斯高帕斯（Scopus）

摘要

Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10^{- 14}; OR = 3.94; 95% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown

原文	英語
頁（從 - 到）	36-39
頁數	4
期刊	Clinical Immunology
卷	129
發行號	1
DOIs	https://doi.org/10.1016/j.clim.2008.05.011
出版狀態	已出版 - 10 2008
對外發佈	是

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10.1016/j.clim.2008.05.011

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Lin, Y. J., Wan, L., Sheu, J. J. C., Huang, C. M., Lin, C. W., Lan, Y. C., Lai, C. H., Hung, C. H., Tsai, Y., Tsai, C. H., Lin, W. Y., Liu, H. P., Lin, T. H., Huang, Y. M., & Tsai, F. J. (2008). G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan. Clinical Immunology, 129(1), 36-39. https://doi.org/10.1016/j.clim.2008.05.011

@article{7dd5616dbfe648ada554930169211537,

title = "G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan",

abstract = "Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10- 14; OR = 3.94; 95\% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95\% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95\% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown",

keywords = "Interleukin-2, Single nucleotide polymorphism, Systemic lupus erythematosus",

author = "Lin, \{Ying Ju\} and Lei Wan and Sheu, \{Jim Jinn Chyuan\} and Huang, \{Chung Ming\} and Lin, \{Cheng Wen\} and Lan, \{Yu Ching\} and Lai, \{Chih Ho\} and Hung, \{Chien Hui\} and Yuhsin Tsai and Tsai, \{Chang Hai\} and Lin, \{Wei Yong\} and Liu, \{Hsin Ping\} and Lin, \{Ting Hsu\} and Huang, \{Yu Min\} and Tsai, \{Fuu Jen\}",

year = "2008",

month = oct,

doi = "10.1016/j.clim.2008.05.011",

language = "英语",

volume = "129",

pages = "36--39",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

AU - Lin, Ying Ju

AU - Wan, Lei

AU - Sheu, Jim Jinn Chyuan

AU - Huang, Chung Ming

AU - Lin, Cheng Wen

AU - Lan, Yu Ching

AU - Lai, Chih Ho

AU - Hung, Chien Hui

AU - Tsai, Yuhsin

AU - Tsai, Chang Hai

AU - Lin, Wei Yong

AU - Liu, Hsin Ping

AU - Lin, Ting Hsu

AU - Huang, Yu Min

AU - Tsai, Fuu Jen

PY - 2008/10

Y1 - 2008/10

N2 - Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10- 14; OR = 3.94; 95% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown

AB - Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10- 14; OR = 3.94; 95% CI = 2.74-5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01-17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19-0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE. Crown

KW - Interleukin-2

KW - Single nucleotide polymorphism

KW - Systemic lupus erythematosus

UR - https://www.scopus.com/pages/publications/51249087516

U2 - 10.1016/j.clim.2008.05.011

DO - 10.1016/j.clim.2008.05.011

M3 - 文章

C2 - 18650128

AN - SCOPUS:51249087516

SN - 1521-6616

VL - 129

SP - 36

EP - 39

JO - Clinical Immunology

JF - Clinical Immunology

IS - 1

ER -

G/T polymorphism in the interleukin-2 exon 1 region among Han Chinese systemic lupus erythematosus patients in Taiwan

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