Harnessing and honing mesenchymal stem/stromal cells for the amelioration of graft-versus-host disease

Tang Her Jaing*, Tsung Yen Chang, Chia Chi Chiu

*此作品的通信作者

研究成果: 期刊稿件文獻綜述同行評審

摘要

Allogeneic hematopoietic stem cell transplantation is a deterministic curative procedure for various hematologic disorders and congenital immunodeficiency. Despite its increased use, the mortality rate for patients undergoing this procedure remains high, mainly due to the perceived risk of exacerbating graft-versus-host disease (GVHD). However, even with immunosuppressive agents, some patients still develop GVHD. Advanced mesenchymal stem/stromal cell (MSC) strategies have been proposed to achieve better therapeutic outcomes, given their immunosuppressive potential. However, the efficacy and trial designs have varied among the studies, and some research findings appear contradictory due to the challenges in characterizing the in vivo effects of MSCs. This review aims to provide real insights into this clinical entity, emphasizing diagnostic, and therapeutic considerations and generating pathophysiology hypotheses to identify research avenues. The indications and timing for the clinical application of MSCs are still subject to debate.

原文英語
頁(從 - 到)221-234
頁數14
期刊World Journal of Stem Cells
15
發行號4
DOIs
出版狀態已出版 - 26 04 2023

文獻附註

©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

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