Identification of chronic obstructive pulmonary disease subgroups in 13 Asian cities

W. J. Kim; V. Gupta; M. Nishimura; H. Makita; L. Idolor; C. Roa; L. C. Loh; C. K. Ong; J. S. Wang; W. Boonsawat; K. D. Gunasekera; D. Madegedara; H. P. Kuo; C. H. Wang; C. Wang; T. Yang; Y. X. Lin; F. W.S. Ko; D. S.C. Hui; L. T.T. Lan; Q. T.T. Vu; A. B. Bhome; A. Ng; J. B. Seo; B. Y. Lee; J. S. Lee; Y. M. Oh; S. D. Lee

doi:10.5588/ijtld.17.0524

Identification of chronic obstructive pulmonary disease subgroups in 13 Asian cities

W. J. Kim, V. Gupta, M. Nishimura, H. Makita, L. Idolor, C. Roa, L. C. Loh, C. K. Ong, J. S. Wang, W. Boonsawat, K. D. Gunasekera, D. Madegedara, H. P. Kuo, C. H. Wang, C. Wang, T. Yang, Y. X. Lin, F. W.S. Ko, D. S.C. Hui, L. T.T. LanQ. T.T. Vu, A. B. Bhome, A. Ng, J. B. Seo, B. Y. Lee, J. S. Lee, Y. M. Oh, S. D. Lee^*

^*此作品的通信作者

醫學系

研究成果: 期刊稿件 › 文章 › 同行評審

6 引文斯高帕斯（Scopus）

摘要

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition that can differ in its clinical manifestation, structural changes and response to treatment. OBJECTIVE: To identify subgroups of COPD with distinct phenotypes, evaluate the distribution of phenotypes in four related regions and calculate the 1-year change in lung function and quality of life according to subgroup. METHODS: Using clinical characteristics, we performed factor analysis and hierarchical cluster analysis in a cohort of 1676 COPD patients from 13 Asian cities. We compared the 1-year change in forced expiratory volume in one second (FEV ₁ ), modified Medical Research Council dyspnoea scale score, St George's Respiratory Questionnaire (SGRQ) score and exacerbations according to subgroup derived from cluster analysis. RESULTS: Factor analysis revealed that body mass index, Charlson comorbidity index, SGRQ total score and FEV ₁ were principal factors. Using these four factors, cluster analysis identified three distinct subgroups with differing disease severity and symptoms. Among the three subgroups, patients in subgroup 2 (severe disease and more symptoms) had the most frequent exacerbations, most rapid FEV ₁ decline and greatest decline in SGRQ total score. CONCLUSION: Three subgroups with differing severities and symptoms were identified in Asian COPD subjects.

原文	英語
頁（從 - 到）	820-826
頁數	7
期刊	International Journal of Tuberculosis and Lung Disease
卷	22
發行號	7
DOIs	https://doi.org/10.5588/ijtld.17.0524
出版狀態	已出版 - 01 07 2018

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© 2018 The Union.

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10.5588/ijtld.17.0524

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Kim, W. J., Gupta, V., Nishimura, M., Makita, H., Idolor, L., Roa, C., Loh, L. C., Ong, C. K., Wang, J. S., Boonsawat, W., Gunasekera, K. D., Madegedara, D., Kuo, H. P., Wang, C. H., Wang, C., Yang, T., Lin, Y. X., Ko, F. W. S., Hui, D. S. C., ... Lee, S. D. (2018). Identification of chronic obstructive pulmonary disease subgroups in 13 Asian cities. International Journal of Tuberculosis and Lung Disease, 22(7), 820-826. https://doi.org/10.5588/ijtld.17.0524

@article{de7902a57c26484495bc04f0a144b7ee,

title = "Identification of chronic obstructive pulmonary disease subgroups in 13 Asian cities",

abstract = " BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition that can differ in its clinical manifestation, structural changes and response to treatment. OBJECTIVE: To identify subgroups of COPD with distinct phenotypes, evaluate the distribution of phenotypes in four related regions and calculate the 1-year change in lung function and quality of life according to subgroup. METHODS: Using clinical characteristics, we performed factor analysis and hierarchical cluster analysis in a cohort of 1676 COPD patients from 13 Asian cities. We compared the 1-year change in forced expiratory volume in one second (FEV 1 ), modified Medical Research Council dyspnoea scale score, St George's Respiratory Questionnaire (SGRQ) score and exacerbations according to subgroup derived from cluster analysis. RESULTS: Factor analysis revealed that body mass index, Charlson comorbidity index, SGRQ total score and FEV 1 were principal factors. Using these four factors, cluster analysis identified three distinct subgroups with differing disease severity and symptoms. Among the three subgroups, patients in subgroup 2 (severe disease and more symptoms) had the most frequent exacerbations, most rapid FEV 1 decline and greatest decline in SGRQ total score. CONCLUSION: Three subgroups with differing severities and symptoms were identified in Asian COPD subjects.",

keywords = "COPD, Cluster analysis, Dyspnoea, Lung function decline",

author = "Kim, {W. J.} and V. Gupta and M. Nishimura and H. Makita and L. Idolor and C. Roa and Loh, {L. C.} and Ong, {C. K.} and Wang, {J. S.} and W. Boonsawat and Gunasekera, {K. D.} and D. Madegedara and Kuo, {H. P.} and Wang, {C. H.} and C. Wang and T. Yang and Lin, {Y. X.} and Ko, {F. W.S.} and Hui, {D. S.C.} and Lan, {L. T.T.} and Vu, {Q. T.T.} and Bhome, {A. B.} and A. Ng and Seo, {J. B.} and Lee, {B. Y.} and Lee, {J. S.} and Oh, {Y. M.} and Lee, {S. D.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Union.",

year = "2018",

month = jul,

day = "1",

doi = "10.5588/ijtld.17.0524",

language = "英语",

volume = "22",

pages = "820--826",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union Against Tuberculosis and Lung Disease ",

number = "7",

}

Kim, WJ, Gupta, V, Nishimura, M, Makita, H, Idolor, L, Roa, C, Loh, LC, Ong, CK, Wang, JS, Boonsawat, W, Gunasekera, KD, Madegedara, D, Kuo, HP, Wang, CH, Wang, C, Yang, T, Lin, YX, Ko, FWS, Hui, DSC, Lan, LTT, Vu, QTT, Bhome, AB, Ng, A, Seo, JB, Lee, BY, Lee, JS, Oh, YM & Lee, SD 2018, 'Identification of chronic obstructive pulmonary disease subgroups in 13 Asian cities', International Journal of Tuberculosis and Lung Disease, 卷 22, 編號 7, 頁 820-826. https://doi.org/10.5588/ijtld.17.0524

TY - JOUR

T1 - Identification of chronic obstructive pulmonary disease subgroups in 13 Asian cities

AU - Kim, W. J.

AU - Gupta, V.

AU - Nishimura, M.

AU - Makita, H.

AU - Idolor, L.

AU - Roa, C.

AU - Loh, L. C.

AU - Ong, C. K.

AU - Wang, J. S.

AU - Boonsawat, W.

AU - Gunasekera, K. D.

AU - Madegedara, D.

AU - Kuo, H. P.

AU - Wang, C. H.

AU - Wang, C.

AU - Yang, T.

AU - Lin, Y. X.

AU - Ko, F. W.S.

AU - Hui, D. S.C.

AU - Lan, L. T.T.

AU - Vu, Q. T.T.

AU - Bhome, A. B.

AU - Ng, A.

AU - Seo, J. B.

AU - Lee, B. Y.

AU - Lee, J. S.

AU - Oh, Y. M.

AU - Lee, S. D.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition that can differ in its clinical manifestation, structural changes and response to treatment. OBJECTIVE: To identify subgroups of COPD with distinct phenotypes, evaluate the distribution of phenotypes in four related regions and calculate the 1-year change in lung function and quality of life according to subgroup. METHODS: Using clinical characteristics, we performed factor analysis and hierarchical cluster analysis in a cohort of 1676 COPD patients from 13 Asian cities. We compared the 1-year change in forced expiratory volume in one second (FEV 1 ), modified Medical Research Council dyspnoea scale score, St George's Respiratory Questionnaire (SGRQ) score and exacerbations according to subgroup derived from cluster analysis. RESULTS: Factor analysis revealed that body mass index, Charlson comorbidity index, SGRQ total score and FEV 1 were principal factors. Using these four factors, cluster analysis identified three distinct subgroups with differing disease severity and symptoms. Among the three subgroups, patients in subgroup 2 (severe disease and more symptoms) had the most frequent exacerbations, most rapid FEV 1 decline and greatest decline in SGRQ total score. CONCLUSION: Three subgroups with differing severities and symptoms were identified in Asian COPD subjects.

AB - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition that can differ in its clinical manifestation, structural changes and response to treatment. OBJECTIVE: To identify subgroups of COPD with distinct phenotypes, evaluate the distribution of phenotypes in four related regions and calculate the 1-year change in lung function and quality of life according to subgroup. METHODS: Using clinical characteristics, we performed factor analysis and hierarchical cluster analysis in a cohort of 1676 COPD patients from 13 Asian cities. We compared the 1-year change in forced expiratory volume in one second (FEV 1 ), modified Medical Research Council dyspnoea scale score, St George's Respiratory Questionnaire (SGRQ) score and exacerbations according to subgroup derived from cluster analysis. RESULTS: Factor analysis revealed that body mass index, Charlson comorbidity index, SGRQ total score and FEV 1 were principal factors. Using these four factors, cluster analysis identified three distinct subgroups with differing disease severity and symptoms. Among the three subgroups, patients in subgroup 2 (severe disease and more symptoms) had the most frequent exacerbations, most rapid FEV 1 decline and greatest decline in SGRQ total score. CONCLUSION: Three subgroups with differing severities and symptoms were identified in Asian COPD subjects.

KW - COPD

KW - Cluster analysis

KW - Dyspnoea

KW - Lung function decline

UR - http://www.scopus.com/inward/record.url?scp=85049228123&partnerID=8YFLogxK

U2 - 10.5588/ijtld.17.0524

DO - 10.5588/ijtld.17.0524

M3 - 文章

C2 - 29914609

AN - SCOPUS:85049228123

SN - 1027-3719

VL - 22

SP - 820

EP - 826

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 7

ER -

Identification of chronic obstructive pulmonary disease subgroups in 13 Asian cities

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