Identification of human papillomavirus DNA sequences in peripheral blood mononuclear cells

C. C. Pao; S. S. Lin; C. Y. Lin; J. S. Maa; C. H. Lai; T. T. Hsieh

doi:10.1093/ajcp/95.4.540

Identification of human papillomavirus DNA sequences in peripheral blood mononuclear cells

C. C. Pao^*, S. S. Lin, C. Y. Lin, J. S. Maa, C. H. Lai, T. T. Hsieh

^*此作品的通信作者

Chang Gung University

研究成果: 期刊稿件 › 文章 › 同行評審

76 引文斯高帕斯（Scopus）

摘要

Polymerase chain reaction (PCR) was used to amplify and identify the presence of the DNA of human papillomavirus (HPV) types 6, 11, 16, and 18 in peripheral blood mononuclear cells (PBMCs) of women with and without urogenital HPV infections. HPV DNA of various types was found in PBMCs of 13 of 25 (52.0%) patients with urogenital HPV infections and in none of the 19 control subjects who are free of urogenital HPV infections. The presence of HPV DNA in PBMCs may impair the immunologic functions of the lymphocytes and play a role in the epidemiology of HPV infections and the pathogenesis of HPV-induced diseases.

原文	英語
頁（從 - 到）	540-546
頁數	7
期刊	American Journal of Clinical Pathology
卷	95
發行號	4
DOIs	https://doi.org/10.1093/ajcp/95.4.540
出版狀態	已出版 - 1991

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title = "Identification of human papillomavirus DNA sequences in peripheral blood mononuclear cells",

abstract = "Polymerase chain reaction (PCR) was used to amplify and identify the presence of the DNA of human papillomavirus (HPV) types 6, 11, 16, and 18 in peripheral blood mononuclear cells (PBMCs) of women with and without urogenital HPV infections. HPV DNA of various types was found in PBMCs of 13 of 25 (52.0%) patients with urogenital HPV infections and in none of the 19 control subjects who are free of urogenital HPV infections. The presence of HPV DNA in PBMCs may impair the immunologic functions of the lymphocytes and play a role in the epidemiology of HPV infections and the pathogenesis of HPV-induced diseases.",

keywords = "Blood cells, Genital diseases, Human papillomavirus, Polymerase chain reaction, Sexually transmitted diseases",

author = "Pao, {C. C.} and Lin, {S. S.} and Lin, {C. Y.} and Maa, {J. S.} and Lai, {C. H.} and Hsieh, {T. T.}",

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AU - Pao, C. C.

AU - Lin, S. S.

AU - Lin, C. Y.

AU - Maa, J. S.

AU - Lai, C. H.

AU - Hsieh, T. T.

PY - 1991

Y1 - 1991

N2 - Polymerase chain reaction (PCR) was used to amplify and identify the presence of the DNA of human papillomavirus (HPV) types 6, 11, 16, and 18 in peripheral blood mononuclear cells (PBMCs) of women with and without urogenital HPV infections. HPV DNA of various types was found in PBMCs of 13 of 25 (52.0%) patients with urogenital HPV infections and in none of the 19 control subjects who are free of urogenital HPV infections. The presence of HPV DNA in PBMCs may impair the immunologic functions of the lymphocytes and play a role in the epidemiology of HPV infections and the pathogenesis of HPV-induced diseases.

AB - Polymerase chain reaction (PCR) was used to amplify and identify the presence of the DNA of human papillomavirus (HPV) types 6, 11, 16, and 18 in peripheral blood mononuclear cells (PBMCs) of women with and without urogenital HPV infections. HPV DNA of various types was found in PBMCs of 13 of 25 (52.0%) patients with urogenital HPV infections and in none of the 19 control subjects who are free of urogenital HPV infections. The presence of HPV DNA in PBMCs may impair the immunologic functions of the lymphocytes and play a role in the epidemiology of HPV infections and the pathogenesis of HPV-induced diseases.

KW - Blood cells

KW - Genital diseases

KW - Human papillomavirus

KW - Polymerase chain reaction

KW - Sexually transmitted diseases

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DO - 10.1093/ajcp/95.4.540

M3 - 文章

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SN - 0002-9173

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JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

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ER -

Identification of human papillomavirus DNA sequences in peripheral blood mononuclear cells

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