Imaging the availability of serotonin transporter in rat brain with I-ADAM and small-animal SPECT

Li Chung Hwang; Chia Jung Chang; Hsueh Hsuan Liu; Hung Chun Kao; Shih Ying Lee; Meei Ling Jan; Chia Chieh Chen

doi:10.1097/MNM.0b013e32825a67cb

Imaging the availability of serotonin transporter in rat brain with I-ADAM and small-animal SPECT

Li Chung Hwang^*
, Chia Jung Chang
, Hsueh Hsuan Liu
, Hung Chun Kao
, Shih Ying Lee
, Meei Ling Jan
, Chia Chieh Chen

^*此作品的通信作者

Institute of Nuclear Energy Research Taiwan

研究成果: 期刊稿件 › 文章 › 同行評審

9 引文斯高帕斯（Scopus）

摘要

Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.

原文	英語
頁（從 - 到）	615-621
頁數	7
期刊	Nuclear Medicine Communications
卷	28
發行號	8
DOIs	https://doi.org/10.1097/MNM.0b013e32825a67cb
出版狀態	已出版 - 08 2007
對外發佈	是

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10.1097/MNM.0b013e32825a67cb

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abstract = "Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.",

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AU - Hwang, Li Chung

AU - Chang, Chia Jung

AU - Liu, Hsueh Hsuan

AU - Kao, Hung Chun

AU - Lee, Shih Ying

AU - Jan, Meei Ling

AU - Chen, Chia Chieh

PY - 2007/8

Y1 - 2007/8

N2 - Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.

AB - Imaging serotonin transporters during antidepressant treatment in small animals is a useful tool for preclinical study during drug development. In this work, we aimed to demonstrate the feasibility of using I-ADAM and small-animal SPECT to monitor serotonin transporter availabilities in rat brains prior to and after administration of a selective serotonin re-uptake inhibitor.

KW - Serotonin transporter

KW - Small-animal SPECT

UR - https://www.scopus.com/pages/publications/34447563770

U2 - 10.1097/MNM.0b013e32825a67cb

DO - 10.1097/MNM.0b013e32825a67cb

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AN - SCOPUS:34447563770

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JF - Nuclear Medicine Communications

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ER -

Imaging the availability of serotonin transporter in rat brain with I-ADAM and small-animal SPECT

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