TY - JOUR
T1 - Impact of antidiabetic medications on physical and cognitive functioning of older Mexican Americans with diabetes mellitus
T2 - A population-based cohort study
AU - Wu, Jasmanda H.
AU - Haan, Mary N.
AU - Liang, Jersey
AU - Ghosh, Debashis
AU - Gonzalez, Hector M.
AU - Herman, William H.
PY - 2003/5
Y1 - 2003/5
N2 - PURPOSE: The current study was designed to evaluate the utility of antidiabetic medications in affecting changes in physical and cognitive functioning among older Mexican Americans with diabetes over a 2-year period. METHODS: A longitudinal analysis with repeated measurements between 1999 and 2001 was performed in a cohort of Mexican Americans, 60 or older, in the SALSA Project. Statistical analysis was conducted using a generalized estimating equation. RESULTS: For subjects with diagnosed diabetes ≤ 5 years (N = 381), there was less decline in physical and cognitive functioning over 2 years among subjects on treatment, compared to those without treatment. For subjects with diagnosed diabetes of 5+ years (N = 337), the effect of antidiabetic medications was more significant in preventing the decline in physical and cognitive functioning (ADL: mean in log scale = -0.10, 95% CI = -0.16, -0.04, 3MS: mean = 6.35, 95% CI = 3.23, 9.48). Combination therapy of antidiabetic agents appeared to be more effective than monotherapy in preventing the decline in physical and cognitive functioning for subjects. CONCLUSIONS: Antidiabetic drugs appear to be useful in alleviating the decline in physical and cognitive functioning among older Mexican Americans with diabetes, especially for those with a longer duration of the disease.
AB - PURPOSE: The current study was designed to evaluate the utility of antidiabetic medications in affecting changes in physical and cognitive functioning among older Mexican Americans with diabetes over a 2-year period. METHODS: A longitudinal analysis with repeated measurements between 1999 and 2001 was performed in a cohort of Mexican Americans, 60 or older, in the SALSA Project. Statistical analysis was conducted using a generalized estimating equation. RESULTS: For subjects with diagnosed diabetes ≤ 5 years (N = 381), there was less decline in physical and cognitive functioning over 2 years among subjects on treatment, compared to those without treatment. For subjects with diagnosed diabetes of 5+ years (N = 337), the effect of antidiabetic medications was more significant in preventing the decline in physical and cognitive functioning (ADL: mean in log scale = -0.10, 95% CI = -0.16, -0.04, 3MS: mean = 6.35, 95% CI = 3.23, 9.48). Combination therapy of antidiabetic agents appeared to be more effective than monotherapy in preventing the decline in physical and cognitive functioning for subjects. CONCLUSIONS: Antidiabetic drugs appear to be useful in alleviating the decline in physical and cognitive functioning among older Mexican Americans with diabetes, especially for those with a longer duration of the disease.
KW - Antidiabetic drugs
KW - Diabetes mellitus
KW - Mexican Americans
KW - Physical and cognitive functioning
UR - http://www.scopus.com/inward/record.url?scp=0038460824&partnerID=8YFLogxK
U2 - 10.1016/S1047-2797(02)00464-7
DO - 10.1016/S1047-2797(02)00464-7
M3 - 文章
C2 - 12821276
AN - SCOPUS:0038460824
SN - 1047-2797
VL - 13
SP - 369
EP - 376
JO - Annals of Epidemiology
JF - Annals of Epidemiology
IS - 5
ER -
