Impact of cholesterol on disease progression

Chun Jung Lin, Cheng Kuo Lai, Min Chuan Kao, Lii Tzu Wu, U. Ging Lo, Li Chiung Lin, Yu An Chen, Ho Lin, Jer Tsong Hsieh, Chih Ho Lai, Chia Der Lin*

*此作品的通信作者

研究成果: 期刊稿件文章同行評審

27 引文 斯高帕斯(Scopus)

摘要

Cholesterol-rich microdomains (also called lipid rafts), where platforms for signaling are provided and thought to be associated with microbe-induced pathogenesis and lead to cancer progression. After treatment of cells with cholesterol disrupting or usurping agents, raft-associated proteins and lipids can be dissociated, and this renders the cell structure nonfunctional and therefore mitigates disease severity. This review focuses on the role of cholesterol in disease progression including cancer development and infectious diseases. Understanding the molecular mechanisms of cholesterol in these diseases may provide insight into the development of novel strategies for controlling these diseases in clinical scenarios.

原文英語
頁(從 - 到)1-7
頁數7
期刊BioMedicine (Netherlands)
5
發行號2
DOIs
出版狀態已出版 - 01 06 2015
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© Author(s) 2015.

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